Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Satellitosis, a Crosstalk Between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour

Prospero Civita
* ORCID logo ,
Valerio Ortenzi
ORCID logo ,
Antonio Giuseppe Naccarato
,
Mark Gumbleton
,
Geoffry J. Pilkington
*
Version 1 : Received: 20 November 2020 / Approved: 21 November 2020 / Online: 21 November 2020 (08:41:01 CET)

A peer-reviewed article of this Preprint also exists.

Civita, P.; Valerio, O.; Naccarato, A.G.; Gumbleton, M.; Pilkington, G.J. Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour. Cancers 2020, 12, 3720. Civita, P.; Valerio, O.; Naccarato, A.G.; Gumbleton, M.; Pilkington, G.J. Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour. Cancers 2020, 12, 3720.

Abstract

The secondary structures of Scherer commonly known as perineuronal and perivascular satellitosis have been identified as a histopathological hallmark of diffuse, invasive, high-grade gliomas. They are recognized as perineuronal satellitosis when clusters of neoplastic glial cells surround neurons cell bodies and perivascular satellitosis when such tumour cells surround blood vessels infiltrating Virchow-Robin spaces. In this review, we provide an overview of emerging knowledge regarding how interactions between neurons and glioma cells can modulate tumour evolution and how neurons play a key role in glioma growth and progression, as well as the role of perivascular satellitosis into mechanisms of glioma cells spread. At the same time, we review the current knowledge about the role of perineuronal satellitosis and perivascular satellitosis within the tumour microenvironment (TME), in order to highlight critical knowledge gaps in research space.

Keywords

brain tumour; satellitosis; tumour heterogeneity; glioblastoma; perineuronal satellitosis; perivascular satellitosis; invasion

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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