Version 1
: Received: 13 November 2020 / Approved: 13 November 2020 / Online: 13 November 2020 (14:15:57 CET)
How to cite:
Garg, E.; Koche, S.; Mehdi, S. Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy. Preprints2020, 2020110386. https://doi.org/10.20944/preprints202011.0386.v1
Garg, E.; Koche, S.; Mehdi, S. Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy. Preprints 2020, 2020110386. https://doi.org/10.20944/preprints202011.0386.v1
Garg, E.; Koche, S.; Mehdi, S. Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy. Preprints2020, 2020110386. https://doi.org/10.20944/preprints202011.0386.v1
APA Style
Garg, E., Koche, S., & Mehdi, S. (2020). Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy. Preprints. https://doi.org/10.20944/preprints202011.0386.v1
Chicago/Turabian Style
Garg, E., Sandhya Koche and Saher Mehdi. 2020 "Personalised Therapeutic and Dietary Interventions as an Alternative Non-Invasive Management of Temporal Lobe Epilepsy" Preprints. https://doi.org/10.20944/preprints202011.0386.v1
Abstract
A 12 year old boy was diagnosed with temporal lobe epilepsy (TLE) along with mesial temporal sclerosis based on MRI (magnetic resonance imaging) results. The diagnosis was further confirmed by genetic analysis. He also had minor psychiatric symptoms of obsessive-compulsive disorders and mood swings. After 4 years of treatment with Sodium Valproate no change in symptoms was observed. Genetic testing along with deep phenotyping revealed altered glutamate pathway and metabolism. Post genetic testing the patient was put on a combination of Sodium Valproate and Valproic acid along with supplementation of N-acetylcysteine (NAC), Cyanocobalamin, Pyridoxine and Cholecalciferol. Within three months of this combined therapy the patient experienced complete elimination of seizures and drastic improvement in mood and social behaviour. The case report highlights the importance of precision diagnosis in understanding the underlying perturbed pathways in structural epilepsy like TLE and demonstrates the importance of non-invasive targeted therapy in such cases.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
