Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Autoimmune Concept Of Schizophrenia: HIistorical Roots and Current Facets

Version 1 : Received: 2 November 2020 / Approved: 3 November 2020 / Online: 3 November 2020 (12:53:38 CET)

How to cite: Mayorova, M.; Butoma, B.; Churilov, L.; Gilburd, B.; Petrova, N.; Shoenfeld, Y. Autoimmune Concept Of Schizophrenia: HIistorical Roots and Current Facets. Preprints 2020, 2020110147 (doi: 10.20944/preprints202011.0147.v1). Mayorova, M.; Butoma, B.; Churilov, L.; Gilburd, B.; Petrova, N.; Shoenfeld, Y. Autoimmune Concept Of Schizophrenia: HIistorical Roots and Current Facets. Preprints 2020, 2020110147 (doi: 10.20944/preprints202011.0147.v1).

Abstract

The review analyzes a possible role of autoimmune processes in the pathogenesis of schizophrenia and evolution of concepts on this issue from its origin to present. Risks of autoimmune processes causing schizophrenia are associated with several factors: an impaired functioning of dopaminergic and glutamatergic systems in the brain, kynurenine pathway disorder with overproduction of quinolinic, anthranilic and kynurenic acids (possibly altering both neurons and T-regulators), increased intestinal permeability, as well as food antigens’ effects, stress and infections with various pathogens at different stages of ontogenesis. An increase in the levels of proinflammatory cytokines and chemokines as well as a decrease in the levels of anti-inflammatory ones also may contribute to schizophrenia risks. Schizophrenia often occurs in those patients having various autoimmune diseases and their first-degree relatives. Cases of schizophrenia resulted from autoimmune pathogenesis (including autoimmune encephalitis caused by autoantibodies against various neuronal antigens) are characterized by quite severe cognitive and psychotic symptoms and less favorable prognosis. This severe course may result from the chronic immune damage of the neuronal receptors such as NMDA, GABA, and others and depend on hyperprolactinemia, induced by antipsychotics, but aggravating autoimmune processes [with 2 tables, 4 figures, bibliography: 99 references].

Subject Areas

antineuronal autoantibodies; autoimmune diseases; autoimmune encephalitis; food antigens; kynurenine pathway; microbiota; prolactin; cytokines; schizophrenia; stress

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.