Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Antieukaryotic Type Six Secretion System Virulence Factors of Bacteria

Version 1 : Received: 31 October 2020 / Approved: 2 November 2020 / Online: 2 November 2020 (16:07:25 CET)
Version 2 : Received: 9 November 2020 / Approved: 10 November 2020 / Online: 10 November 2020 (16:10:18 CET)

How to cite: Maphosa, S.; Moleleki, L.; Motaung, T. Antieukaryotic Type Six Secretion System Virulence Factors of Bacteria. Preprints 2020, 2020110062 (doi: 10.20944/preprints202011.0062.v2). Maphosa, S.; Moleleki, L.; Motaung, T. Antieukaryotic Type Six Secretion System Virulence Factors of Bacteria. Preprints 2020, 2020110062 (doi: 10.20944/preprints202011.0062.v2).

Abstract

The type 6 protein secretion system (T6SS) is prevalently utilized by Gram-negative bacteria to compete for resources and space. Upon activation, toxic effectors from this secretion system are translocated into the competitor prokaryote or eukaryote in a contact-dependent manner. While much has been reported on T6SS-mediated prokaryotic competition, very little is understood about the mechanisms of bacterial interactions with eukaryotic hosts. Likewise, many virulent T6SS effectors are known to be antibacterial. In recent years, however, evidence has emerged on numerous T6SS effectors that interact with related immunity proteins in a range of eukaryotic hosts. Insights into how this effector-immunity pairing alters the physiological responses of the recipient organism might provide opportunities relating to the T6SS agricultural and biotherapeutic applications. We, therefore, summarize the impacts of the T6SS effectors with a special focus on bacterial interactions with animals, plants, and fungi. We further briefly discuss pipelines that are currently used to characterize antieukaryotic T6SS effectors.

Subject Areas

Type VI Secretion System; antieukaryotic effectors; interkingdom competition; virulence

Comments (1)

Comment 1
Received: 10 November 2020
Commenter: Silindile Maphosa
Commenter's Conflict of Interests: Author
Comment: Figure 1 and Table 1 have been changed. Additional important information has been added to the antifungal T6SS effectors section.
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