Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Novel Earwax Method to Measure Acute and Chronic Glucose Levels

Version 1 : Received: 13 October 2020 / Approved: 14 October 2020 / Online: 14 October 2020 (10:52:13 CEST)

How to cite: Herane-Vives, A.; Espinoza, S.; Sandoval, R.; Ortega, L.; Alameda, L.; Young, A.H.; Arnone, D.; Hayes, A.; Benohr, J. A Novel Earwax Method to Measure Acute and Chronic Glucose Levels. Preprints 2020, 2020100302 (doi: 10.20944/preprints202010.0302.v1). Herane-Vives, A.; Espinoza, S.; Sandoval, R.; Ortega, L.; Alameda, L.; Young, A.H.; Arnone, D.; Hayes, A.; Benohr, J. A Novel Earwax Method to Measure Acute and Chronic Glucose Levels. Preprints 2020, 2020100302 (doi: 10.20944/preprints202010.0302.v1).

Abstract

Increased chronic glucose is associated with pandemic diseases. To date, there is not a practical, as well as accurate sample for reflecting that level. We measured earwax glucose in 37 controls. They provided standard serum samples, Glycated Haemoglobin (HbA1c) and earwax samples on two time-points, one month a part. The specimens measured baseline fasting glucose, a follow-up postprandial glucose level and a between sample chronic glucose, calculated using the average level on the two occasions. The baseline earwax sample was obtained using a clinical method and the follow-up using a novel self-sampling earwax device. The earwax analytic time was significantly faster using the novel device in comparison to the clinical use of the syringe. Earwax accurately reflected glucose at both assessments with stronger correlations than HbA1c. Follow-up postprandial concentrations were more significant than their respective fasting baseline concentrations, reflecting differences in fasting and postprandial glycaemia and more efficient standardisation at follow up. Earwax demonstrated to be more predictable than HbA1c in reflecting systemic fasting, postprandial and long-term glucose levels and immune by confounders. Earwax glucose was approximately 60% more predictable than HbA1c in reflecting glycaemia over a month. The self-sampling device provided a sample that might accurately reflect chronic glycaemia.

Subject Areas

Earwax; Glucose; Glycated Haemoglobin; Diabetes; diagnosis

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