Implications of Engaging in Regular Exercise and Reducing Sedentary Behavior During a Global Pandemic: An Immuno-metabolic Perspective in Patients with Obesity and Type 2 Diabetes

Jabeur Methnani; Dorra Amor; Narimen Yousfi; Ali Bouslama; Asma Omezzine; Ezdine Bouhlel

doi:10.20944/preprints202010.0270.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 October 2020 / Approved: 13 October 2020 / Online: 13 October 2020 (09:48:59 CEST)

Many reports showed a dramatic decrease in the levels of physical activity during the current pandemic of SARS-COV-2. This has substantial immunometabolic implications, especially in those at risk or with metabolic diseases including individuals with obesity and Type 2 diabetes. Here we discuss the route from physical inactivity to immnometabolic aberrancies; focusing on how insulin resistance could represent an adaptive mechanism to the low physical activity levels and/or high energy intake and on how such an adaptive mechanism could derail to be a pathognomonic feature of metabolic diseases creating a vicious circle of immune and metabolic aberrancies. We provide a theoretical framework to the severe immunopathology of COVID-19 in patients with metabolic diseases. We finally discuss the idea of exercise as a potential adjuvant against COVID-19 and emphasize how even interrupting prolonged periods of sitting with short time breaks of very light activity could be a feasible strategy to limit the deleterious effects of sedentary behavior.

sedentism; exercise; immunometabolism; SARS-COV-2; Cytokines; immunity

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Implications of Engaging in Regular Exercise and Reducing Sedentary Behavior During a Global Pandemic: An Immuno-metabolic Perspective in Patients with Obesity and Type 2 Diabetes

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