Thom, C.S.; Chou, S.T.; French, D.L. Mechanistic and Translational Advances Using iPSC-Derived Blood Cells. Preprints2020, 2020090672. https://doi.org/10.20944/preprints202009.0672.v1
APA Style
Thom, C.S., Chou, S.T., & French, D.L. (2020). Mechanistic and Translational Advances Using iPSC-Derived Blood Cells. Preprints. https://doi.org/10.20944/preprints202009.0672.v1
Chicago/Turabian Style
Thom, C.S., Stella T. Chou and Deborah L. French. 2020 "Mechanistic and Translational Advances Using iPSC-Derived Blood Cells" Preprints. https://doi.org/10.20944/preprints202009.0672.v1
Abstract
Human induced pluripotent stem cell (iPSC)-based model systems can be used to produce blood cells for the study of both hematologic and non-hematologic disorders. This commentary discusses recent advances that have utilized iPSC-derived red blood cells, megakaryocytes, myeloid cells, and lymphoid cells to model hematopoietic disorders. In addition, we review recent studies that have defined how microglial cells differentiated from iPSC-derived monocytes impact neurodegenerative disease. Related translational insights highlight the utility of iPSC models for studying pathologic anemia, bleeding, thrombosis, autoimmunity, immunodeficiency, blood cancers, and neurodegenerative disease such as Alzheimer’s.
Keywords
iPSC; hematopoiesis; developmental biology; anemia; thrombosis; immunodeficiency; cancer
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
