Working Paper Article Version 1 This version is not peer-reviewed

Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Version 1 : Received: 22 September 2020 / Approved: 23 September 2020 / Online: 23 September 2020 (04:52:34 CEST)

How to cite: Mat Ali, M.H.; Yaacob, N.M.; Yahaya, N.; Draman, N.; Wan Mohamed, W.M.I.; Abdullah, M.S.; Wan Azman, W.N.; Ibrahim, H.A.; Wan Nik, W.N.F.H.; Mohamed, M.; Tuan Ismail, T.S. Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study. Preprints 2020, 2020090538 Mat Ali, M.H.; Yaacob, N.M.; Yahaya, N.; Draman, N.; Wan Mohamed, W.M.I.; Abdullah, M.S.; Wan Azman, W.N.; Ibrahim, H.A.; Wan Nik, W.N.F.H.; Mohamed, M.; Tuan Ismail, T.S. Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study. Preprints 2020, 2020090538

Abstract

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n=64, hyperthyroid; n=53 euthyroid; and n=18, hypothyroid) and healthy controls (n=64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). Results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The bone marker levels were significantly high in the hyperthyroid group and low in the hypothyroid group. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In all groups, the serum vitamin D levels were below the cutoff value. However, thyroid patients had a higher serum vitamin D level than healthy controls. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. Further, hyperthyroid patients had a low hip BMD.

Subject Areas

Hyperthyroid; Hypothyroid; Euthyroid; Vitamin D; Bone Turn Over Markers; Bone Mineral Density

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