Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

ACEII Gene Analysis Exposes SARS-CoV-2 As A Potential Threat to Agricultural and National Security

Version 1 : Received: 14 September 2020 / Approved: 16 September 2020 / Online: 16 September 2020 (03:57:36 CEST)

How to cite: Ruhl, M.; Jenkins, T. ACEII Gene Analysis Exposes SARS-CoV-2 As A Potential Threat to Agricultural and National Security. Preprints 2020, 2020090345 (doi: 10.20944/preprints202009.0345.v1). Ruhl, M.; Jenkins, T. ACEII Gene Analysis Exposes SARS-CoV-2 As A Potential Threat to Agricultural and National Security. Preprints 2020, 2020090345 (doi: 10.20944/preprints202009.0345.v1).

Abstract

Coronavirus is now a significant human pathogen with the emergence of SARS-CoV-2. Until now there has been no data to support a threat to agricultural industries. Using a comparative genomic protein analysis, this study examined the angiotensin-converting enzyme II (ACEII) gene of 17 animal species with an emphasis on agriculture. To determine viral vulnerability the 20 known SARS-CoV-2 receptor-binding domain (RBD)/ACEII receptor interaction sites were compared to determine their potential susceptibility to the SARS-CoV-2 virus. With the known bat host’s (XP_032963186) number of binding sites as a threshold, we note that ALL animal species examined in this study contained significant numbers (≥10) of SARS-CoV-2 binding sites and could be at risk for SARS-CoV-2 infection. The data from this study suggest SARS-CoV-2 imposes a grave threat to the safety and security of the agricultural industry. Urgent studies are needed to determine if infected animals can transmit SARS-CoV-2 before and/or after processing.

Subject Areas

food safety; SARS-CoV-2; coronavirus; ACEII; agricultural security; national security

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