Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis

Version 1 : Received: 12 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (23:45:55 CEST)

How to cite: Schilke, R.; Blackburn, C.; Bamgbose, T.; Woolard, M. Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis. Preprints 2020, 2020090301 (doi: 10.20944/preprints202009.0301.v1). Schilke, R.; Blackburn, C.; Bamgbose, T.; Woolard, M. Interface of Phospholipase Activity, Immune Cell Function, and Atherosclerosis. Preprints 2020, 2020090301 (doi: 10.20944/preprints202009.0301.v1).

Abstract

Phospholipases are a family of lipid altering enzymes that can either reduce or increase bioactive lipid levels. Bioactive lipids elicit signaling responses, activate transcription factors, promote g-coupled protein activity, and modulate membrane fluidity that mediate cellular function. Phospholipases and the bioactive lipids they produce are important regulators on immune cell activity, dictating both pro-inflammatory and pro-resolving activity. During atherosclerosis, pro-inflammatory and pro-resolving activities govern atherosclerosis progression and regression respectively. This review will look at the interface of phospholipase activity, immune cell function, and atherosclerosis.

Subject Areas

Atherosclerosis; Phospholipases; Macrophages; T cells; Lipins

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