Version 1
: Received: 24 August 2020 / Approved: 25 August 2020 / Online: 25 August 2020 (11:47:20 CEST)
How to cite:
Son, E.; Choi, H. J.; Kim, S.-H.; Jang, D.-G.; Cha, J.; Choi, J. J.; Kim, M. R.; Kim, D.-S. Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance. Preprints2020, 2020080552
Son, E.; Choi, H. J.; Kim, S.-H.; Jang, D.-G.; Cha, J.; Choi, J. J.; Kim, M. R.; Kim, D.-S. Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance. Preprints 2020, 2020080552
Son, E.; Choi, H. J.; Kim, S.-H.; Jang, D.-G.; Cha, J.; Choi, J. J.; Kim, M. R.; Kim, D.-S. Anti-Diabetic Effects of Wild Soybean Glycine Soja Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance. Preprints2020, 2020080552
APA Style
Son, E., Choi, H. J., Kim, S. H., Jang, D. G., Cha, J., Choi, J. J., Kim, M. R., & Kim, D. S. (2020). <strong>Anti-Diabetic Effects of Wild Soybean <em>Glycine Soja</em> Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance</strong>. Preprints. https://doi.org/
Chicago/Turabian Style
Son, E., Mee Ree Kim and Dong-Seon Kim. 2020 "<strong>Anti-Diabetic Effects of Wild Soybean <em>Glycine Soja</em> Seed Extract on Type 2 Diabetic Mice and Human Hepatocytes Induced Insulin Resistance</strong>" Preprints. https://doi.org/
Abstract
Anti-diabetic effects of Glycine soja seed extract (GS) on Type 2 diabetes mellitus mouse model and human hepatocytes induced insulin resistance were investigated. 3 weeks old db/db mice were divided into 5 groups (n = 6) including two control groups and 3 GS treated groups with different doses. Oral administration of GS for 6 weeks to diabetic db/db mice reduced blood glucose level significantly in a dose dependent manner by 44.7% (300 mg/kg/day), 30.9% (150 mg/kg/day) and 21.1% (75 mg/kg/day). GS treatment also lowered significantly plasma level of HbA1c, insulin, IGF-1 and leptin, and increased that of adiponectin. GS treatment activated AMPK, and down-regulated GLUT2 in liver tissues of mice while up-regulated GLUT4 in muscle tissues of mice. In in vitro study with insulin resistance induced human hepatocyte, GS treatment increased glucose uptake and increased the activities of Akt and PPAR-γ in response to insulin. Treatment of GS appears to reduce blood glucose level by regulating energy metabolism positively through various metabolic pathways and reducing insulin resistance in Type 2 diabetes mellitus.
Keywords
Glycine soja seed; Type 2 diabetes mellitus; Antidiabetic; AMPK; Akt; PPAR-γ
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
