Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Indoor PM10 Upregulates Pro-inflammatory Mediators in Bronchial Epithelial Cells

Version 1 : Received: 13 August 2020 / Approved: 14 August 2020 / Online: 14 August 2020 (09:22:59 CEST)

How to cite: zhang, C.; Asif, H.; Calcagno, T.M.; Kumar, N.; Fregien, N.L.; Mirsaeidi, M. Indoor PM10 Upregulates Pro-inflammatory Mediators in Bronchial Epithelial Cells. Preprints 2020, 2020080315 (doi: 10.20944/preprints202008.0315.v1). zhang, C.; Asif, H.; Calcagno, T.M.; Kumar, N.; Fregien, N.L.; Mirsaeidi, M. Indoor PM10 Upregulates Pro-inflammatory Mediators in Bronchial Epithelial Cells. Preprints 2020, 2020080315 (doi: 10.20944/preprints202008.0315.v1).

Abstract

Indoor dusts are collectively formed from anthropogenic and atmospheric activities. Particle matter 10 (PM10) is inhalable and causes significant inflammation by interaction with the pulmonary epithelial barrier. The mediators involved in bronchial epithelial cells response to dust are remined unknown. The air-liquid interface of our lung on chip model was exposed to indoor dust collected from highly polluted houses in Delhi, India. The media were collected after 4 days and cytokine levels were measured. We found that the concentration of IFN, IFNγ, Interleukin-6 (IL-6), IL1b, TNFa, and Granulocyte monocyte colony stimulating factor (GM-CSF) were significantly increased after exposure to indoor dust. IFN type I pathways were a major response from dust exposure. Further investigation is needed to determine the mechanism of action and targets of dust in bronchial epithelial cells.

Subject Areas

Indoor; PM10; pulmonary disease; inflammation; IFN; type I interferon; cytokine; epithelial cell

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.