Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection

Version 1 : Received: 3 August 2020 / Approved: 4 August 2020 / Online: 4 August 2020 (11:28:48 CEST)

A peer-reviewed article of this Preprint also exists.

Yeh, C.-Y.; Schulien, A.J.; Molyneaux, B.J.; Aizenman, E. Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection. Int. J. Mol. Sci. 2020, 21, 6107. Yeh, C.-Y.; Schulien, A.J.; Molyneaux, B.J.; Aizenman, E. Lessons from Recent Advances in Ischemic Stroke Management and Targeting Kv2.1 for Neuroprotection. Int. J. Mol. Sci. 2020, 21, 6107.

Journal reference: Int. J. Mol. Sci. 2020, 21, 6107
DOI: 10.3390/ijms21176107

Abstract

Achieving neuroprotection in ischemic stroke patients has been a multi-decade medical challenge. Numerous clinical trials were discontinued in futility and many were terminated in response to deleterious treatment effects. Recently however, several positive reports have generated the much-needed excitement surrounding stroke therapy. In this review, we describe the clinical studies that significantly expanded the time window of eligibility for patients to receive mechanical endovascular thrombectomy. We summarize the results available thus far for nerinetide, which can be considered the most promising neuroprotective agent yet for stroke treatment. Lastly, we reflect upon aspects of these successful trials in our own studies targeting the Kv2.1-mediated cell death pathway in neurons for neuroprotection. We propose that recent changes in the clinical landscape must be adapted by preclinical research in order to continue progressing toward the development of efficacious neuroprotective therapies for ischemic stroke.

Subject Areas

Ischemic Stroke; Reperfusion; Neuroprotection; Nerinetide; Kv2.1

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