Version 1
: Received: 30 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (10:47:08 CEST)
How to cite:
Gowthaman, U.; García-Pichardo, D.; Jin, Y.; Schwarz, I.; Marquardt, S. DNA Processing in The Context of Non-Coding Transcription. Preprints2020, 2020070744. https://doi.org/10.20944/preprints202007.0744.v1
Gowthaman, U.; García-Pichardo, D.; Jin, Y.; Schwarz, I.; Marquardt, S. DNA Processing in The Context of Non-Coding Transcription. Preprints 2020, 2020070744. https://doi.org/10.20944/preprints202007.0744.v1
Gowthaman, U.; García-Pichardo, D.; Jin, Y.; Schwarz, I.; Marquardt, S. DNA Processing in The Context of Non-Coding Transcription. Preprints2020, 2020070744. https://doi.org/10.20944/preprints202007.0744.v1
APA Style
Gowthaman, U., García-Pichardo, D., Jin, Y., Schwarz, I., & Marquardt, S. (2020). <strong>DNA Processing in The Context of Non-Coding Transcription</strong>. Preprints. https://doi.org/10.20944/preprints202007.0744.v1
Chicago/Turabian Style
Gowthaman, U., Isabel Schwarz and Sebastian Marquardt. 2020 "<strong>DNA Processing in The Context of Non-Coding Transcription</strong>" Preprints. https://doi.org/10.20944/preprints202007.0744.v1
Abstract
RNA polymerase II (RNAPII) frequently transcribes non-protein coding DNA sequences in eukaryotic genomes into long non-coding RNA (lncRNA). Here, we focus on the impact of the act of lncRNA transcription on nearby functional DNA units. Distinct molecular mechanisms linked to the position of lncRNA relative to the coding gene illustrate how non-coding transcription controls gene expression. We review the biological significance of the act of lncRNA transcription on DNA processing, highlighting common themes, such as mediating cellular responses to environmental changes. This review presents the background in chromatin signaling to appreciate examples in different organisms where we can interpret functions of non-coding DNA through the act of RNAPII transcription.
Keywords
long non-coding RNA (lncRNA); RNA polymerase II (RNAPII) transcription; gene regulation; tandem transcriptional interference (tTI); antisense transcription; DNA processing
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
