Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Time to RNA Negative Conversion in Moroccan COVID-19 Patients: A Single-Centre Experience

Imane Smyej
,
Leila Jeddane
* ,
Idrissa Diawara
,
Jalila Rahoui
,
Nida Meskaouni
,
Rachid Benmessaoud
,
Khadija Arouro
,
Khadij Jaras
,
Hind Rida
,
Fatima Zahra Moujid
,
Zahra Adam
,
Salma Nahir
,
Zineb Aouzal
,
Hajar Elguezzar
,
Fadwa Ousti
,
Houda Benrahma
* ,
Jalila El Bakkouri
Version 1 : Received: 26 June 2020 / Approved: 28 June 2020 / Online: 28 June 2020 (10:00:38 CEST)

How to cite: Smyej, I.; Jeddane, L.; Diawara, I.; Rahoui, J.; Meskaouni, N.; Benmessaoud, R.; Arouro, K.; Jaras, K.; Rida, H.; Moujid, F.Z.; Adam, Z.; Nahir, S.; Aouzal, Z.; Elguezzar, H.; Ousti, F.; Benrahma, H.; El Bakkouri, J. Time to RNA Negative Conversion in Moroccan COVID-19 Patients: A Single-Centre Experience. Preprints 2020, 2020060334. https://doi.org/10.20944/preprints202006.0334.v1 Smyej, I.; Jeddane, L.; Diawara, I.; Rahoui, J.; Meskaouni, N.; Benmessaoud, R.; Arouro, K.; Jaras, K.; Rida, H.; Moujid, F.Z.; Adam, Z.; Nahir, S.; Aouzal, Z.; Elguezzar, H.; Ousti, F.; Benrahma, H.; El Bakkouri, J. Time to RNA Negative Conversion in Moroccan COVID-19 Patients: A Single-Centre Experience. Preprints 2020, 2020060334. https://doi.org/10.20944/preprints202006.0334.v1

Abstract

The COVID-19 global pandemic is now a public health emergency in Morocco. Reports on factors associated with prolonged viral shedding are not consistent. In this retrospective laboratory based study, time to RNA negative conversion is reported in a series of 129 patients monitored in a single laboratory in Casablanca. Risk factors associated with delayed negative conversion have been evaluated, by chi-squared test. Median delay of negative conversion was 22.5 days (IQR 17.75-29.0) from illness onset. Neither gender nor age were particularly associated with delayed viral clearance. Delayed time to hospital admission and disease severity were associated with prolonged viral shedding in this series. We recommend early diagnosis and treatment onset to reduce time to viral clearance and transmissibility of SARS-CoV-2 virus.

Keywords

SARS-CoV-2; COVID-19; Morocco; recovery; viral clearance

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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