Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cardiovascular Risk Factors and Evolution of Patients Attended with COVID-19 in a National Reference Hospital from Lima, Peru

Version 1 : Received: 18 June 2020 / Approved: 19 June 2020 / Online: 19 June 2020 (10:22:50 CEST)

How to cite: Valenzuela, G.V.; Rodriguez-Morales, A.J.; Mamani, R.; Ayala, R.; Pérez, K.; Sarmiento, C.; Calcino, J.; García, L.; Amado, J. Cardiovascular Risk Factors and Evolution of Patients Attended with COVID-19 in a National Reference Hospital from Lima, Peru. Preprints 2020, 2020060237 (doi: 10.20944/preprints202006.0237.v1). Valenzuela, G.V.; Rodriguez-Morales, A.J.; Mamani, R.; Ayala, R.; Pérez, K.; Sarmiento, C.; Calcino, J.; García, L.; Amado, J. Cardiovascular Risk Factors and Evolution of Patients Attended with COVID-19 in a National Reference Hospital from Lima, Peru. Preprints 2020, 2020060237 (doi: 10.20944/preprints202006.0237.v1).

Abstract

Coronavirus disease 2019 (COVID-19) fatal outcomes have been associated with multiple cardiovascular risk factors. In new epidemic areas, such as Latin America, there is a lack of studies about this. Here, we evaluated those factors in a retrospective cohort of patients in a national reference hospital of Lima, Peru. Design. A retrospective cohort observational study was done. For this study, information was obtained from clinical records of the hospital for the cases that were laboratory-diagnosed and related, during March 6th and April 30th, 2020. rRT-PCR was used for the detection of the RNA of SARS-CoV-2 following the protocol Charité, Berlin, Germany, from nasopharyngeal swabs at the National Institute of Health. Calculation of the odds ratio (OR) with the respective 95% confidence interval (95% CI) was done, also logistic regression for adjusted OR (multivariate) was done. Values of p < 0.05 were considered significant for all analyses. Results. One hundred six hospitalized patients were evaluated. The mean age of patients was 61.58 years (SD 16.81). Cardiovascular risk factors among them were hypertension (46.2%), diabetes (28.3%), and obesity (28.3%), among others. Fifty-six patients died (52.8%). Mortality associated factors at the multivariate analysis were arterial hypertension (OR=1.343, 95% 1.089-1.667), myocardial injury (OR=1.303, 95% 1.031-1.642), and mechanical ventilation (OR 1.262, 95% 1.034-1.665), as associated factors. Conclusion. As observed in other regions of the world, cardiovascular risk factors represent a significant and independent threat to be considered in patients with COVID-19. Further studies and interventions in Peru and Latin America are expected.

Subject Areas

COVID-19; SARS-CoV-2; risk factors; outcomes; cardiovascular; Latin America.

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