Preprint Article Version 1 This version is not peer-reviewed

Determination of Antibiotic Residue in Milk and Assessment of Human Health Risk in Bangladesh

Version 1 : Received: 14 June 2020 / Approved: 17 June 2020 / Online: 17 June 2020 (13:25:29 CEST)

How to cite: Rahman, M.; Hassan, M.; Chowdhury, S. Determination of Antibiotic Residue in Milk and Assessment of Human Health Risk in Bangladesh. Preprints 2020, 2020060221 (doi: 10.20944/preprints202006.0221.v1). Rahman, M.; Hassan, M.; Chowdhury, S. Determination of Antibiotic Residue in Milk and Assessment of Human Health Risk in Bangladesh. Preprints 2020, 2020060221 (doi: 10.20944/preprints202006.0221.v1).

Abstract

Consumption of milk contaminated with antibiotic residues above the maximum residue limit (MRL) causes direct toxicity to humans and the development of superbugs that leads to the failure of antibiotic therapy and threatens human life. Besides, long-duration exposure might alter the nature of gut microflora results in the enhancement of many diseases. Therefore, we examined 300 raw and processed packet milk samples using thin layer chromatography (TLC) and ultra high performance liquid chromatography (UHPLC) method against five veterinary antibiotics and assessed the risk for consumers in Chattogram, Bangladesh. Risk analysis was calculated by using hazard quotient on the basis of 165 ml per capita milk consumption. We found a total of 7% prevalence of antibiotic residues in raw milk samples which were higher (8%) in individual samples than the pooled samples (4%). However, we did not find any processed packet milk samples as positive. The mean concentration of oxytetracycline residue was detected 61.29 µg/l and amoxicillin was 124 µg/l in individual milk samples. Risk analysis showed the hazard quotient values of 0.0056 for oxytetracycline and 0.0017 for amoxicillin residue which was confirmed that, no significant health risk associated with the consumption of milk produced and marketed in the study area. Our study might fill the gap of knowledge to measure the safety status of milk regarding public health issues.

Subject Areas

antibiotic residue; human health; milk; risk assessment; TLC; UHPLC

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