Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Lessons for SARS-CoV-2 Study (COVID-19 Disease) From Its Exosome Relatives

Version 1 : Received: 11 June 2020 / Approved: 12 June 2020 / Online: 12 June 2020 (09:01:02 CEST)

How to cite: Arsene, P. Lessons for SARS-CoV-2 Study (COVID-19 Disease) From Its Exosome Relatives. Preprints 2020, 2020060145 (doi: 10.20944/preprints202006.0145.v1). Arsene, P. Lessons for SARS-CoV-2 Study (COVID-19 Disease) From Its Exosome Relatives. Preprints 2020, 2020060145 (doi: 10.20944/preprints202006.0145.v1).

Abstract

Our first modern global pandemic is caused by a nanosized lipid vesicle, called SARS-CoV-2. Its molecular structure and biogenesis have remarkable similarities with Extracellular Vesicles (EVs, most notably exosomes) that are constantly shed by all cells during their life. Their resemblance may not be a coincidence. Growing body of evidence has shown that EVs have significant roles in various biological processes, including viral infection, transmission and anti-viral response. Drawing comparison with the virus might shed light on how we could fight the COVID-19 disease. This may include novel EV research and diagnostics technologies as well as novel EV-based treatments.

Subject Areas

SARS-CoV-2; COVID-19; Exosome; Extracellular Vesicle; Diagnostics; Vaccine; Treatment

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