Working Paper Review Version 1 This version is not peer-reviewed

Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19

Version 1 : Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (11:31:17 CEST)

How to cite: Nigro, E.; Polito, R.; Alfieri, A.; Mancini, A.; Imperlini, E.; Elce, A.; Krustrup, P.; Orrù, S.; Buono, P.; Daniele, A. Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19 . Preprints 2020, 2020060084 Nigro, E.; Polito, R.; Alfieri, A.; Mancini, A.; Imperlini, E.; Elce, A.; Krustrup, P.; Orrù, S.; Buono, P.; Daniele, A. Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19 . Preprints 2020, 2020060084

Abstract

Purpose: At a time of a pandemic SARS-CoV2 infection, and in the context of the multiorgan crosstalk widely accepted as a mechanism participating in the pathophysiology of all organs and systems, a correlation between adipose tissue, muscle and the immune system has been investigated. Physical Activity (PA) represents the first line of defence against metabolic diseases and infections, like SARS-CoV2, modulating several crucial functions such as inflammation and immune response. Conversely, obesity, type 2 diabetes and cardiovascular disorders – all correlated with PA - negatively impact on general health status, including susceptibility to infections. Here we review the complex interplay between type 2 diabetes, obesity, immune response, inflammation and viral infections, such as the current SARS-CoV2, focusing on the molecular mechanisms modulated by exercise. Methods: A comprehensive literature search was completed to identify joint biomarkers previously used to investigate acute and chronic exercise training. Results: we show that PA may counteract/mitigate viral adverse effects. We also describe data suggesting that vitamin D supplementation, frequently observed in practitioners of sport and regular exercise, could represent an additional positive factor in supporting COVID-19 with fighting against the virus. Conclusion: Altogether this evidence confirms that an active lifestyle and PA not only counteract dysmetabolic diseases but could also be effective for counteracting SARS-CoV2 infection. It is therefore essential to persuade people to keep active.

Subject Areas

Physical Activity; COVID-19; healthy lifestyle; metabolic disorders; immune system

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