Nigro, E.; Polito, R.; Alfieri, A.; Mancini, A.; Imperlini, E.; Elce, A.; Krustrup, P.; Orrù, S.; Buono, P.; Daniele, A. Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19. Preprints2020, 2020060084
APA Style
Nigro, E., Polito, R., Alfieri, A., Mancini, A., Imperlini, E., Elce, A., Krustrup, P., Orrù, S., Buono, P., & Daniele, A. (2020). Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19. Preprints. https://doi.org/
Chicago/Turabian Style
Nigro, E., Pasqualina Buono and Aurora Daniele. 2020 "Molecular Mechanisms Involved in the Positive Effects of Physical Activity on Coping with COVID-19" Preprints. https://doi.org/
Abstract
Purpose:At a time of a pandemic SARS-CoV2 infection, and in the context of the multiorgan crosstalk widely accepted as a mechanism participating in the pathophysiology of all organs and systems, a correlation between adipose tissue, muscle and the immune system has been investigated. Physical Activity (PA) represents the first line of defence against metabolic diseases and infections, like SARS-CoV2, modulating several crucial functions such as inflammation and immune response. Conversely, obesity, type 2 diabetes and cardiovascular disorders – all correlated with PA - negatively impact on general health status, including susceptibility to infections. Here we review the complex interplay between type 2 diabetes, obesity, immune response, inflammation and viral infections, such as the current SARS-CoV2, focusing on the molecular mechanisms modulated by exercise. Methods: A comprehensive literature search was completed to identify joint biomarkers previously used to investigate acute and chronic exercise training. Results: we show that PA may counteract/mitigate viral adverse effects. We also describe data suggesting that vitamin D supplementation, frequently observed in practitioners of sport and regular exercise, could represent an additional positive factor in supporting COVID-19 with fighting against the virus. Conclusion: Altogether this evidence confirms that an active lifestyle and PA not only counteract dysmetabolic diseases but could also be effective for counteracting SARS-CoV2 infection. It is therefore essential to persuade people to keep active.
Keywords
Physical Activity; COVID-19; healthy lifestyle; metabolic disorders; immune system
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
