Version 1
: Received: 2 June 2020 / Approved: 3 June 2020 / Online: 3 June 2020 (08:53:12 CEST)
How to cite:
Vlasov, S.; Postnikov, P.; Belousov, M.; Krivoshchekov, S.; Yusubov, M.; Guryev, A.; Di Martino, A. Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds. Preprints2020, 2020060014. https://doi.org/10.20944/preprints202006.0014.v1
Vlasov, S.; Postnikov, P.; Belousov, M.; Krivoshchekov, S.; Yusubov, M.; Guryev, A.; Di Martino, A. Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds. Preprints 2020, 2020060014. https://doi.org/10.20944/preprints202006.0014.v1
Vlasov, S.; Postnikov, P.; Belousov, M.; Krivoshchekov, S.; Yusubov, M.; Guryev, A.; Di Martino, A. Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds. Preprints2020, 2020060014. https://doi.org/10.20944/preprints202006.0014.v1
APA Style
Vlasov, S., Postnikov, P., Belousov, M., Krivoshchekov, S., Yusubov, M., Guryev, A., & Di Martino, A. (2020). Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds. Preprints. https://doi.org/10.20944/preprints202006.0014.v1
Chicago/Turabian Style
Vlasov, S., Artem Guryev and Antonio Di Martino. 2020 "Multiresponsive Hybrid Microparticles for Stimuli-Responsive Delivery of Bioactive Compounds" Preprints. https://doi.org/10.20944/preprints202006.0014.v1
Abstract
Hybrid microparticles based on an iron core and amphiphilic shell have been prepared to respond simultaneously to external (magnetic and ultrasounds field) and internal (pH) stimuli for delivery of the anticancer drug doxorubicin. The microparticles have been prepared in three main steps; including surface modification of the iron core followed by conjugation with the amphiphilic chitosan and drug loading. The particles demonstrate spherical shape and dimension in the range 1-3 m with tunable surface charge by changing the pH of surrounding environment. The microparticles demonstrate good stability in simulated physiological solutions and able to allocate up to 400 g of drug per mg of bare carrier. The response to ultrasound and the changes in the shell structure when exposed to different pH allows to control the doxorubicin release. In vitro cytotoxicity tests performed on fibloblast NIH/3T3 demonstrate a reduction in the cell viability when doxorubicin was administrated by microparticles compared to the free formulation; in particular when ultrasound were applied. The bare microparticles demonstrate cytocompatibility and hemocompatibility up to 50g/mL and 60 g/mL, respectively.
Keywords
Core-shell microparticles; ultrasound; amphiphilic polymer; magnetic microparticles; doxorubicin
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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