Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Single Arm Study to Evaluate the Transfer of Drospirenone to Breast Milk after Reaching Steady State after Oral Administration of 4 MG Drospirenone Only Pill in Healthy Lactating Female Volunteers

Version 1 : Received: 23 May 2020 / Approved: 24 May 2020 / Online: 24 May 2020 (20:26:11 CEST)

How to cite: Melka, D.; Kask, K.; Colli, E.; Regidor, P. A Single Arm Study to Evaluate the Transfer of Drospirenone to Breast Milk after Reaching Steady State after Oral Administration of 4 MG Drospirenone Only Pill in Healthy Lactating Female Volunteers. Preprints 2020, 2020050406 (doi: 10.20944/preprints202005.0406.v1). Melka, D.; Kask, K.; Colli, E.; Regidor, P. A Single Arm Study to Evaluate the Transfer of Drospirenone to Breast Milk after Reaching Steady State after Oral Administration of 4 MG Drospirenone Only Pill in Healthy Lactating Female Volunteers. Preprints 2020, 2020050406 (doi: 10.20944/preprints202005.0406.v1).

Abstract

Objective: The primary objective of this trial was to assess the transfer of drospirenone to breast milk after daily administration of an oral test preparation containing 4 mg of drospirenone at the steady state. The secondary objective of the trial was to assess the safety of the preparation based on safety clinical and laboratory measurements (at the beginning and at the end of the trial) and reporting of adverse events and/or adverse drug reactions. Patients and Methods: This was an open label, non-comparative single center study. Drospirenone 4mg per day was the first postpartum contraceptive for the study participants who were no longer breastfeeding yet were still lactating. It was administered for 7 (seven) days to achieve steady-state concentration. All participants were volunteers who planned to use oral contraceptives as their family planning method in the future. Results: A total number of 12 volunteers completed the trial according to the protocol and the samples of all the 12 study completers were analyzed. The average concentration-time curve of drospirenone in plasma 24 h after the administration of the last dose (AUC(0-24h)) was 635.33 ng*h/mL and 120 h after the single repeat dose administration (AUC(0-120h) was 1180.57 ng*h/mL, respectively. The average Cmax was 48.64 ng/mL. The average concentration-time curve of drospirenone in milk 24 h after the administration of the last dose (AUC(0-24h)) was 134.35 ng*h/mL and 120 h after the single repeat dose administration (AUC(0-120h) was 227.17 ng*h/mL respectively. The average Cmax was 10.34 ng/mL. Conclusion: On average 18.13% of plasma drospirenone made it to breast milk and the highest concentration of drospirenone in breast milk was 17.55% of that in plasma. The total quantity of drospirenone passing to breast milk is on average 4478 ng during a 24 h period representing 0.11% of the maternal daily dose. Thus, at the recommended doses, no effects on breastfed newborns/infants are anticipated with drospirenone 4 mg.

Subject Areas

Drospirenone 4mg; breastfeeding; plasma concentration; milk concentration

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