Preprint Article Version 1 This version is not peer-reviewed

Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes

Version 1 : Received: 24 May 2020 / Approved: 24 May 2020 / Online: 24 May 2020 (18:25:47 CEST)

How to cite: Rouchka, E.C.; Chariker, J.H.; Chung, D. Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes. Preprints 2020, 2020050396 (doi: 10.20944/preprints202005.0396.v1). Rouchka, E.C.; Chariker, J.H.; Chung, D. Phylogenetic and Variant Analysis of 1,040 SARS-CoV-2 Genomes. Preprints 2020, 2020050396 (doi: 10.20944/preprints202005.0396.v1).

Abstract

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral genome is an RNA virus consisting of approximately 30,000 bases. As part of testing efforts, whole genome sequencing of human isolates has resulted in over 1,600 complete genomes publicly available from GenBank. We have performed a comparative phylogenetic analysis of the sequences, in order to detect common mutations within the population. Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5’ untranslated region (UTR), 152 within the 3’UTR, 2 within intergenic regions and 34 within coding sequences.

Subject Areas

SARS-CoV-2; COVID-19; coronavirus; variant analysis; phylogenetic analysis; viral evolution

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