Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Pilar Sanchis
* ORCID logo ,
Rosmeri Rivera
,
Regina Fortuny
,
Carlos Rio
,
Miguel Mas-Gelabert
,
Marta Gonzalez-Freire
,
Felix Grases
ORCID logo ,
Luis Masmiquel
*
Version 1 : Received: 19 May 2020 / Approved: 21 May 2020 / Online: 21 May 2020 (09:46:56 CEST)

A peer-reviewed article of this Preprint also exists.

Sanchis, P.; Rivera, R.; Fortuny, R.; Río, C.; Mas-Gelabert, M.; Gonzalez-Freire, M.; Grases, F.; Masmiquel, L. Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus. J. Clin. Med. 2020, 9, 1751. Sanchis, P.; Rivera, R.; Fortuny, R.; Río, C.; Mas-Gelabert, M.; Gonzalez-Freire, M.; Grases, F.; Masmiquel, L. Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus. J. Clin. Med. 2020, 9, 1751.

Abstract

The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study conducted from January 2017 to June 2018. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify aortic abdominal calcification AAC. Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher number of diabetic related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications.

Keywords

AGEs; aortic calcification; type 2 diabetes mellitus; diabetes-related complications

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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