Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Immunoinformatics-Guided Designing of an Epitope-Based Vaccine against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein

Ahmed Rakib
ORCID logo ,
Saad Ahmed Sami
,
Arkajyoti Paul
ORCID logo ,
Asif Shahriar
,
Abu Montakim Tareq
ORCID logo ,
Nazim Uddin Emon
ORCID logo ,
Nusrat Jahan Mimi
,
Md. Mustafiz Chowdhury
,
Taslima Akter Eva
,
Sajal Chakraborty
,
Sagar Shil
,
Sabrina Jahan Mily
,
Talha Bin Emran
* ORCID logo
Version 1 : Received: 15 May 2020 / Approved: 16 May 2020 / Online: 16 May 2020 (17:07:43 CEST)

How to cite: Rakib, A.; Sami, S.A.; Paul, A.; Shahriar, A.; Tareq, A.M.; Emon, N.U.; Mimi, N.J.; Chowdhury, M.M.; Eva, T.A.; Chakraborty, S.; Shil, S.; Mily, S.J.; Emran, T.B. Immunoinformatics-Guided Designing of an Epitope-Based Vaccine against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein. Preprints 2020, 2020050271. https://doi.org/10.20944/preprints202005.0271.v1 Rakib, A.; Sami, S.A.; Paul, A.; Shahriar, A.; Tareq, A.M.; Emon, N.U.; Mimi, N.J.; Chowdhury, M.M.; Eva, T.A.; Chakraborty, S.; Shil, S.; Mily, S.J.; Emran, T.B. Immunoinformatics-Guided Designing of an Epitope-Based Vaccine against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein. Preprints 2020, 2020050271. https://doi.org/10.20944/preprints202005.0271.v1

Abstract

Currently, with a large number of fatality rates, coronavirus disease-2019 (COVID-19) has emerged as a potential threat to human health worldwide. It has been well-known that severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and World Health Organization (WHO) proclaimed the contagious disease as a global pandemic. Researchers from different parts of the world amalgamate together inquest of remedies for this deadly virus. Recently, it has been demonstrated that the spike glycoprotein (SGP) of SARS-CoV-2 is the mediator behind the entrance into the host cells. Our group has comprehensibly analyzed the SGP of SARS-CoV-2 through multiple sequence analysis along with the phylogenetic analysis. Further, this research work predicted the most immunogenic epitopes for both B-cell and T-cell. Notably, we focused mainly on major histocompatibility complex (MHC) class I potential peptides and predicted two epitopes; WTAGAAAYY and GAAAYYVGY, that bind with the MHC class I alleles which are further validated by molecular docking analysis. Furthermore, this study also proposed that the selected epitopes were shown availability in a greater range of the population. Hence, our study comes up with a strong base for the implementation of designing novel vaccine candidates against SARS-CoV-2, however adequate laboratory works will need to be conducted for the appropriate application.

Keywords

COVID-19; SARS-CoV-2; de novo vaccine; epitope; immunity

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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