Rakib, A., Sami, S.A., Paul, A., Shahriar, A., Tareq, A.M., Emon, N.U., Mimi, N.J., Chowdhury, M.M., Eva, T.A., Chakraborty, S., Shil, S., Mily, S.J., & Emran, T.B. (2020). Immunoinformatics-Guided Designing of an Epitope-Based Vaccine against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein. Preprints. https://doi.org/10.20944/preprints202005.0271.v1
Rakib, A., Sabrina Jahan Mily and Talha Bin Emran. 2020 "Immunoinformatics-Guided Designing of an Epitope-Based Vaccine against Severe Acute Respiratory Syndrome-Coronavirus-2 Spike Glycoprotein" Preprints. https://doi.org/10.20944/preprints202005.0271.v1
Currently, with a large number of fatality rates, coronavirus disease-2019 (COVID-19) has emerged as a potential threat to human health worldwide. It has been well-known that severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and World Health Organization (WHO) proclaimed the contagious disease as a global pandemic. Researchers from different parts of the world amalgamate together inquest of remedies for this deadly virus. Recently, it has been demonstrated that the spike glycoprotein (SGP) of SARS-CoV-2 is the mediator behind the entrance into the host cells. Our group has comprehensibly analyzed the SGP of SARS-CoV-2 through multiple sequence analysis along with the phylogenetic analysis. Further, this research work predicted the most immunogenic epitopes for both B-cell and T-cell. Notably, we focused mainly on major histocompatibility complex (MHC) class I potential peptides and predicted two epitopes; WTAGAAAYY and GAAAYYVGY, that bind with the MHC class I alleles which are further validated by molecular docking analysis. Furthermore, this study also proposed that the selected epitopes were shown availability in a greater range of the population. Hence, our study comes up with a strong base for the implementation of designing novel vaccine candidates against SARS-CoV-2, however adequate laboratory works will need to be conducted for the appropriate application.
COVID-19; SARS-CoV-2; de novo vaccine; epitope; immunity
Biology and Life Sciences, Virology
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