Preprint Article Version 1 This version is not peer-reviewed

Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia

Version 1 : Received: 5 May 2020 / Approved: 6 May 2020 / Online: 6 May 2020 (15:20:27 CEST)

How to cite: Moradi, J. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints 2020, 2020050100 (doi: 10.20944/preprints202005.0100.v1). Moradi, J. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints 2020, 2020050100 (doi: 10.20944/preprints202005.0100.v1).

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the current coronavirus pandemic is an infectious disease that initially confirmed in China in late December 2019. In this study, we analyzed 131 complete sequences of SARS-CoV-2 from Asia. Our results show that there are fifteen major mutations in Asia which most of them are co-evolved. There were five groups based on co-mutations which three of them resulted in clade G including (241C>T, 3037C>T, 14408C>T, and 23403A>G), (28881G>A, 28882G>A, 28883G>C and 23403A>G) and (25563G>T and 23403A>G). Co-mutations in (8782C>T and 28144T>C) and (1397G>A, 28688T>C, 29742G>T and 11083G>T) were clustered in clade S and a new clade outside of GISAID classification, respectively. Sequences with a mutation in 26144G>T had low variability without any co-mutation which formed clade V. In this study, we showed that Most of the circulated viruses in Asia collected in five co-mutation groups which may affect the transmissibility and vaccine designing strategies.

Subject Areas

SARS-CoV-2; Phylogenetics; Asia

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