Version 1
: Received: 5 May 2020 / Approved: 6 May 2020 / Online: 6 May 2020 (15:20:27 CEST)
Version 2
: Received: 13 January 2021 / Approved: 15 January 2021 / Online: 15 January 2021 (13:14:15 CET)
How to cite:
Moradi, J. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints2020, 2020050100. https://doi.org/10.20944/preprints202005.0100.v1
Moradi, J. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints 2020, 2020050100. https://doi.org/10.20944/preprints202005.0100.v1
Moradi, J. Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints2020, 2020050100. https://doi.org/10.20944/preprints202005.0100.v1
APA Style
Moradi, J. (2020). Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia. Preprints. https://doi.org/10.20944/preprints202005.0100.v1
Chicago/Turabian Style
Moradi, J. 2020 "Genomic Characterization and Phylogenetic Analysis of SARS-CoV-2 in Asia" Preprints. https://doi.org/10.20944/preprints202005.0100.v1
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the current coronavirus pandemic is an infectious disease that initially confirmed in China in late December 2019. In this study, we analyzed 131 complete sequences of SARS-CoV-2 from Asia. Our results show that there are fifteen major mutations in Asia which most of them are co-evolved. There werefive groups based on co-mutations which three of them resulted in clade G including (241C>T, 3037C>T, 14408C>T, and 23403A>G), (28881G>A, 28882G>A, 28883G>C and 23403A>G) and (25563G>T and 23403A>G).Co-mutations in (8782C>T and 28144T>C) and (1397G>A, 28688T>C, 29742G>T and 11083G>T) were clustered in clade S and a new clade outside of GISAID classification, respectively. Sequences with a mutation in 26144G>T had low variability without any co-mutation which formed clade V. In this study, we showed that Most of the circulated viruses in Asia collected in five co-mutation groups which may affect the transmissibility and vaccine designing strategies.
Keywords
SARS-CoV-2; Phylogenetics; Asia
Subject
Biology and Life Sciences, Virology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
