Working Paper Review Version 2 This version is not peer-reviewed

Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach, and Systemic Therapy in a Guide for Clinicians

Version 1 : Received: 1 May 2020 / Approved: 2 May 2020 / Online: 2 May 2020 (12:48:23 CEST)
Version 2 : Received: 14 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (04:25:31 CEST)

A peer-reviewed article of this Preprint also exists.

Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers 2020, 12, 2390. Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers 2020, 12, 2390.

Journal reference: Cancers 2020, 12, 2390
DOI: 10.3390/cancers12092390

Abstract

The standard care for metastatic breast cancer (MBC) is systemic therapies with imbrication of focal treatment for symptoms. Recently, thanks to implementation of radiological and metabolic exams and development of new target therapies, oligometastatic and oligoprogressive settings are even more common, paving the way to a paradigm change of focal treatments role. In fact, according to immunophenotype, radiotherapy can be considered with radical intent in these settings of patients. The aim of this literature review is to analyse available clinical data on prognosis of bone metastases from breast cancer and benefits of available treatments for developing a practical guide for clinicians.

Subject Areas

bone metastasis; breast cancer; radiotherapy; diagnostic imaging; systemic therapies

Comments (1)

Comment 1
Received: 20 August 2020
Commenter: Valeria Masiello
Commenter's Conflict of Interests: Author
Comment: Major revision
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