Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Intermolecular Binding of Functional Cyclic Compounds to RNA Nucleotides by an Ionic Process

Version 1 : Received: 29 April 2020 / Approved: 30 April 2020 / Online: 30 April 2020 (08:58:21 CEST)

How to cite: Schaper, C. Intermolecular Binding of Functional Cyclic Compounds to RNA Nucleotides by an Ionic Process. Preprints 2020, 2020040522 (doi: 10.20944/preprints202004.0522.v1). Schaper, C. Intermolecular Binding of Functional Cyclic Compounds to RNA Nucleotides by an Ionic Process. Preprints 2020, 2020040522 (doi: 10.20944/preprints202004.0522.v1).

Abstract

Exogenous RNA comprises the genetic material associated with several diseases which require immediate treatment, and thus mechanisms to hinder intracellular translation and reproduction of RNA viral agents are of great importance. Applying recent developments from this lab in methods relating to the interaction of DNA with steroid hormones, cyclic compounds are presented for intermolecular binding to nucleic acids. The requirements to achieve binding with RNA nucleotide pairs are described, which involve at a minimum functional elements positioned to interact with the lateral phosphate groups for each of the RNA strands through coupling with a positively charged ion, such as Mg2+, Ca2+, or Zn2+ ions; and an intermolecular hydrogen bond with the oxygen element of uracil at the carbon two location. Additional features of the binding molecules are examined for enhancements and differentiation in binding capability and include aromatic groups that have both a structural role of steric hindrance and a functional role to stabilize the binding mechanisms. Several categories of cyclic compounds are associated to have specific binding capabilities, and the interaction of these structures with potential receptor molecules are evaluated for assessment in delivery and binding of the compound to nucleic acids.

Subject Areas

RNA Nucleotides; Uracil; Intermolecular Binding; Cyclic Compounds

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