Version 1
: Received: 24 April 2020 / Approved: 25 April 2020 / Online: 25 April 2020 (11:32:48 CEST)
How to cite:
Al-Fadhel, S.Z.; Al-Ghuraibawi, N.H.A.; Mohammed Ali, D.M.; Al-Hakeim, H.K. Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus. Preprints2020, 2020040463. https://doi.org/10.20944/preprints202004.0463.v1
Al-Fadhel, S.Z.; Al-Ghuraibawi, N.H.A.; Mohammed Ali, D.M.; Al-Hakeim, H.K. Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus. Preprints 2020, 2020040463. https://doi.org/10.20944/preprints202004.0463.v1
Al-Fadhel, S.Z.; Al-Ghuraibawi, N.H.A.; Mohammed Ali, D.M.; Al-Hakeim, H.K. Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus. Preprints2020, 2020040463. https://doi.org/10.20944/preprints202004.0463.v1
APA Style
Al-Fadhel, S.Z., Al-Ghuraibawi, N.H.A., Mohammed Ali, D.M., & Al-Hakeim, H.K. (2020). Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202004.0463.v1
Chicago/Turabian Style
Al-Fadhel, S.Z., Dunia M. Mohammed Ali and Hussein Kadhem Al-Hakeim. 2020 "Serum Cytokine Dependent Hematopoietic Cell Linker (CLNK) as a Predictor for the Duration of Illness in Type 2 Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202004.0463.v1
Abstract
Type 2 diabetes mellitus (T2DM) is an endocrine illness associate with various changes in the immune system and adaptor protein levels. Cytokine dependent hematopoietic cell linker (CLNK) is an adapter protein that regulates immune receptor signaling and acts as a regulator of the receptor signaling of T-cells and natural killer T-cell. The role of CLNK in T2DM is not studied previously. In the present study, serum CLNK level was measured and correlated with some sociodemographic and insulin resistance (IR) parameters. This is achieved by performing measurement of CLNK and insulin parameters (glucose, insulin, and HbA1c in addition to the calculation of the functions of IR (HOMA2IR), insulin sensitivity (HOMA%S), and beta-cell function (HOMA%B)) in 60 T2DM patients and 30 controls. The results indicated a significant increase (p=0.025) in serum CLNK in patients group in comparison with the controls. Multivariategeneralized linear model (GLM) analysis revealed no significant effect of age, BMI, and sex on the CLNK level. The results of tests for between-subjects showed that the CLNK affects diagnosis significantly (F=7.445, p=0.008, partial η2 =0.081) and its effect is approximately the same as the effect of insulin (F=8.107, p=0.006, partial η2 =0.087). The correlation study showed a highly significant positive correlation between CLNK and the duration of disease (rho=0.420, p<0.001). It can be concluded that the increase CLNK in T2DM revealing the role of the adaptor proteins level in the nature of disease. Elevation of CLNK level may be used as a predictor for diabetes complications, which needs more investigations.
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
