Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

An Updated Primer on SARS-CoV-2 and the Evolving Covid-19 Pandemic

Version 1 : Received: 22 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (14:15:59 CEST)
Version 2 : Received: 31 May 2020 / Approved: 1 June 2020 / Online: 1 June 2020 (11:08:03 CEST)

How to cite: Mani, S. An Updated Primer on SARS-CoV-2 and the Evolving Covid-19 Pandemic. Preprints 2020, 2020040449. Mani, S. An Updated Primer on SARS-CoV-2 and the Evolving Covid-19 Pandemic. Preprints 2020, 2020040449.


In this paper we first provide a primer on SARS-CoV-2 and Covid-19 delineating the etiopathogenesis, epidemiology, clinical manifestations and the natural history of the disease. We then trace the evolution of the Covid-19 pandemic highlighting the characteristics of the epidemic in China where the pandemic originated, select countries of Europe which peaked during April, and Brazil, US and India where the pandemic has taken serious turns recently. We also project some possible trajectories for the mega cities of India based on the demographic characteristics of these cities in comparison to New York city. This is an updated version of the article from mid-April published online.


SARS-CoV-2; Covid-19; pandemic; primer; India; mortality rate; evolution; updated primer; evolving pandemic


Public Health and Healthcare, Health Policy and Services

Comments (1)

Comment 1
Received: 1 June 2020
Commenter: Subramani Mani
Commenter's Conflict of Interests: Author
Comment: 1. Analysis and inference is currently based on data available through May 27th, 2020.
2. SARS-CoV-2 genome figure (Figure 2) newly added.
3. SARS-CoV-2 diagnostic test illustration figure (Figure 4) newly added.
4. Epidemiology and Clinical characteristics extensively revised to reflect the current literature on Covid-19.
5. Two new sections (1) Cutaneious manifestations and (2) Children and Covid-19 added.
6. Sections on Drug pipeline and Vaccine trials revised and updated.
7. Section titled Covid-19 pandemic story so far extensively revised and also includes details of outbreak in Russia and Brazil.
8. The projections for India have also been updated based new data available on the outbreak in India.
9. Conclusion section has also been revised to reflect the above-mentioned revisions.
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