Version 1
: Received: 23 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (03:34:21 CEST)
How to cite:
Han, Q.; Peng, J.; Xu, H.; Chen, Q. Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints2020, 2020040424. https://doi.org/10.20944/preprints202004.0424.v1
Han, Q.; Peng, J.; Xu, H.; Chen, Q. Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints 2020, 2020040424. https://doi.org/10.20944/preprints202004.0424.v1
Han, Q.; Peng, J.; Xu, H.; Chen, Q. Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints2020, 2020040424. https://doi.org/10.20944/preprints202004.0424.v1
APA Style
Han, Q., Peng, J., Xu, H., & Chen, Q. (2020). Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints. https://doi.org/10.20944/preprints202004.0424.v1
Chicago/Turabian Style
Han, Q., Hao Xu and Qianming Chen. 2020 "Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV" Preprints. https://doi.org/10.20944/preprints202004.0424.v1
Abstract
The infected and fatal cases of Coronavirus Disease 2019 (COVID-19) keep increasing around the world, to explore the infection routes and pathogenesis of 2019-nCoV could be meaningful for prevention and treatment of COVID-19. Previous studies showed that the oral cavity is at potentially high risk of 2019-nCoV infection. The ACE2 receptor of 2019-nCoV was reported could express on oral epithelium and salivary glands, and 2019-nCoV could be detected in patients’ saliva. Recently, the amblygeustia were found to widely exist in the COVID-19 patients. To explore the potential mechanism of amblygeustia, we performed further analysis via independent in-house single-cell profiles. Our results showed that ACE2 was inclined to express in taste cells, which indicated that 2019-nCoV may invade into taste cells at the early stage of COVID-19, and lead to the amblygeustia of patients. Above findings about the 2019-nCoV and COVID-19 in oral cavity are valuable and enlightening for future epidemic prevention strategy.
Keywords
COVID-19; ACE2; amblygeustia
Subject
Medicine and Pharmacology, Pulmonary and Respiratory Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
