Preprint Brief Report Version 1 This version is not peer-reviewed

Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV

Version 1 : Received: 23 April 2020 / Approved: 24 April 2020 / Online: 24 April 2020 (03:34:21 CEST)

How to cite: Han, Q.; Peng, J.; Xu, H.; Chen, Q. Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints 2020, 2020040424 (doi: 10.20944/preprints202004.0424.v1). Han, Q.; Peng, J.; Xu, H.; Chen, Q. Taste Cell Is Abundant in the Expression of ACE2 Receptor of 2019-nCoV. Preprints 2020, 2020040424 (doi: 10.20944/preprints202004.0424.v1).

Abstract

The infected and fatal cases of Coronavirus Disease 2019 (COVID-19) keep increasing around the world, to explore the infection routes and pathogenesis of 2019-nCoV could be meaningful for prevention and treatment of COVID-19. Previous studies showed that the oral cavity is at potentially high risk of 2019-nCoV infection. The ACE2 receptor of 2019-nCoV was reported could express on oral epithelium and salivary glands, and 2019-nCoV could be detected in patients’ saliva. Recently, the amblygeustia were found to widely exist in the COVID-19 patients. To explore the potential mechanism of amblygeustia, we performed further analysis via independent in-house single-cell profiles. Our results showed that ACE2 was inclined to express in taste cells, which indicated that 2019-nCoV may invade into taste cells at the early stage of COVID-19, and lead to the amblygeustia of patients. Above findings about the 2019-nCoV and COVID-19 in oral cavity are valuable and enlightening for future epidemic prevention strategy.

Subject Areas

COVID-19; ACE2; amblygeustia

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