Article
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Rubidium-82 Generator Yield and Efficiency for PET Perfusion Imaging: Comparison of Two Clinical Systems
Version 1
: Received: 21 April 2020 / Approved: 22 April 2020 / Online: 22 April 2020 (07:32:27 CEST)
How to cite: deKemp, R. Rubidium-82 Generator Yield and Efficiency for PET Perfusion Imaging: Comparison of Two Clinical Systems. Preprints 2020, 2020040393 deKemp, R. Rubidium-82 Generator Yield and Efficiency for PET Perfusion Imaging: Comparison of Two Clinical Systems. Preprints 2020, 2020040393
Abstract
Introduction. Strontium-82/Rubidium-82 (82Sr/82Rb) generators are used widely for positron emission tomography (PET) imaging of myocardial perfusion. In this study, the 82Rb isotope yield and production efficiency of two FDA-approved 82Sr/82Rb generators were compared.Methods. N=515 sequential daily quality assurance (QA) reports from 9 CardioGen-82® and 9 RUBY-FILL® generators were reviewed over a period of 2 years. A series of test elutions was performed at different flow-rates on the RUBY-FILL® system to determine an empirical correction-factor used to convert CardioGen-82® daily QA values of 82Rb activity (dose-calibrator ‘maximum’ of 50 mL elution at 50 mL/min) to RUBY-FILL® equivalent values (integrated ‘total’ of 35 mL elution at 20 mL/min). The generator yield (82Rb) and production efficiency (82Rb yield / 82Sr parent activity) were measured and compared after this conversion to a common scale. Results. At the start of clinical use, the system reported 82Rb activity from daily QA was lower for CardioGen-82® vs RUBY-FILL® (2.3 ± 0.2 vs 3.0 ± 0.2 GBq, p<0.001) despite having similar 82Sr activity. Dose-calibrator ‘maximum’ (CardioGen-82®) values were found to under-estimate the integrated ‘total’ (RUBY-FILL®) activity by ~24% at 50 mL/min. When these data were used to convert the CardioGen-82 values to a common measurement scale (integrated total activity) the CardioGen-82® efficiency remained slightly lower than the RUBY-FILL® system on average (88 ± 4% vs 95 ± 4%, p<0.001). The efficiency of 82Rb production improved for both systems over the respective periods of clinical use.Conclusions. 82Rb generator yield was significantly under-estimated using the CardioGen-82® vs RUBY-FILL® daily QA procedure. When generator yield was expressed as the integrated total activity for both systems, the estimated 82Rb production efficiency of the CardioGen-82® system was ~7% lower than RUBY-FILL® over the full period of clinical use.
Keywords
myocardial perfusion imaging; positron emission tomography; Rubidium-82 generator; daily quality assurance
Subject
Medicine and Pharmacology, Other
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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