Working Paper Article Version 1 This version is not peer-reviewed

Mycophenolate Mofetil Is Active Against SARS-CoV-2 in Vero E6 Cells

Version 1 : Received: 15 April 2020 / Approved: 21 April 2020 / Online: 21 April 2020 (08:19:11 CEST)

How to cite: He, Y.; Pei, R.; Xu, Z.; Chen, Z.; Xiao, S.; Xia, H.; Xiong, J.; Zhu, W.; Zhang, B.; Shen, J. Mycophenolate Mofetil Is Active Against SARS-CoV-2 in Vero E6 Cells. Preprints 2020, 2020040380 He, Y.; Pei, R.; Xu, Z.; Chen, Z.; Xiao, S.; Xia, H.; Xiong, J.; Zhu, W.; Zhang, B.; Shen, J. Mycophenolate Mofetil Is Active Against SARS-CoV-2 in Vero E6 Cells. Preprints 2020, 2020040380

Abstract

Mycophenolate mofetil was reported to have broad in vitro activity against different viruses and had been tried in combination with IFN-β in treating MERS infection. We tested the pharmacological activity of mycophenolate mofetil using SARS-CoV-2 infected Vero cells. The half-maximal effective concentration (EC50) of mycophenolate mofetil against SARS-CoV-2 was 0.47 μM while that of remdesivir was 0.77 μM. Molecular docking results of mycophenolate mofetil to potential target proteins of COVID-19 suggested that mycophenolate mofetil might inhibit SARS-CoV-2 mainly by interacting with DHODH and IMPDH2. Furthermore, mycophenolate mofetil as an immunosuppressant may be a good therapeutic option for the management of hyperinflammation in patients with severe COVID-19. Based on its high potency against SARS-CoV-2 in Vero E6 cells, its good pharmacokinetics and clinical safety profile, mycophenolate mofetil deserves further exploration as potential treatment for COVID-19.

Subject Areas

mycophenolate mofetil; SARS-CoV-2; DHODH; IMPDH2

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.