Version 1
: Received: 20 April 2020 / Approved: 21 April 2020 / Online: 21 April 2020 (06:03:22 CEST)
How to cite:
Gomes de Medeiros Junior, W.L.; Demore, C.C.; Peres Mazaro, L.; Nascimento de Souza, M.F.; Fiuza Parolin, L.; Melo, L.H.; Werka Junior, C.R.; Magno Gonçalves, M.V. Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview. Preprints2020, 2020040376. https://doi.org/10.20944/preprints202004.0376.v1
Gomes de Medeiros Junior, W.L.; Demore, C.C.; Peres Mazaro, L.; Nascimento de Souza, M.F.; Fiuza Parolin, L.; Melo, L.H.; Werka Junior, C.R.; Magno Gonçalves, M.V. Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview. Preprints 2020, 2020040376. https://doi.org/10.20944/preprints202004.0376.v1
Gomes de Medeiros Junior, W.L.; Demore, C.C.; Peres Mazaro, L.; Nascimento de Souza, M.F.; Fiuza Parolin, L.; Melo, L.H.; Werka Junior, C.R.; Magno Gonçalves, M.V. Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview. Preprints2020, 2020040376. https://doi.org/10.20944/preprints202004.0376.v1
APA Style
Gomes de Medeiros Junior, W.L., Demore, C.C., Peres Mazaro, L., Nascimento de Souza, M.F., Fiuza Parolin, L., Melo, L.H., Werka Junior, C.R., & Magno Gonçalves, M.V. (2020). Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview. Preprints. https://doi.org/10.20944/preprints202004.0376.v1
Chicago/Turabian Style
Gomes de Medeiros Junior, W.L., Claudio Rogerio Werka Junior and Marcus Vinicius Magno Gonçalves. 2020 "Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview" Preprints. https://doi.org/10.20944/preprints202004.0376.v1
Abstract
Introduction:Multiple sclerosis (MS) is a demyelinating, chronic, inflammatory and autoimmune disease of the central nervous system (CNS) with axonal degeneration, presenting a progressive and variable course. MS patients usually have complications, such as bladder dysfunction, presence of urinary symptoms and Urinary Tract infection (UTI), which is one of the three most common non-neurological complications in MS patients. Objective:Analyze the most diverse aspects of UTI in MS patients, focusing on risk factors, prevalence, hospitalization and mortality rates of UTIs in this group. Methods: A non-systematic review of articles published on PubMed in the last 10 years with the search terms "Urinary Tract Infection" AND "Multiple Sclerosis". Discussion: MS patients have a high UTI prevalence, mainly due to the occurrence of urinary disorders in these patients. The most common symptoms of UTI in MS patients are urinary urgency, polyuria, nocturia, urinary retention, and incontinence. Escherichia coli, Pseudomonasaeruginosa, and Klebsiella pneumoniae were the most found organisms and treatment is based on antibiotic therapy. Moreover, UTIs can precipitate outbreaks, worsen the disease, causing more damage and a severe neurological condition deterioration. Therefore, UTIs in this group are associated with a high hospitalizations rate and a high mortality rate. Conclusion: UTI represents a great risk and concern in MS patients. The high prevalence, hospitalization rate and mortality rate of UTI in MS is worrying, such as the cause-consequence relationship between UTIs and the use of corticosteroids in outbreaks. Therefore, it is important to be aware of a UTI in this group to make early diagnoses, adequate management, and new infections prevention. Thus, further studies are needed to thoroughly analyze each nuance of this important comorbidity for MS patients.
Keywords
urinary tract infection; multiple sclerosis; hospitalization and mortality rate
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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