Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Early Oxygen Inhalation to Prevent SARS-CoV-2-Induced Acute Respiratory Distress Syndrome

Version 1 : Received: 19 April 2020 / Approved: 20 April 2020 / Online: 20 April 2020 (08:30:29 CEST)
Version 2 : Received: 11 February 2021 / Approved: 11 February 2021 / Online: 11 February 2021 (11:40:30 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: Cells 2021, 10, 1897
DOI: 10.3390/cells10081897


Acute respiratory distress syndrome (ARDS) and the serious complications are the most frequent causes of death of SARS-CoV-2 infection. We bring out a hypothesis that early low-flow oxygen inhalation would maintain the hypoxic pulmonary vasoconstriction (an essential protection mechanism of the lung that optimize gas exchange) and accelerate the re-absorption of pulmonary edema fluid. The optimal time for oxygen therapy was analyzed and four comments are proposed: (1) Finger SpO2 should be measured at home simultaneously with the first-time nucleic acid test. (2) If the patient's SpO2 was lower than the reference value by 2% or more, it is suggested to be hospitalized immediately for standard low-flow oxygen inhalation. (3) If it was not possible to be admitted to hospital immediately, the patient is recommended to take oxygen in the home. (4) The Patients with low SpO2 are advised to use prone position as much as possible.


SARS-CoV-2; acute respiratory distress syndrome; hypoxic pulmonary vasoconstriction; alveolar edema; early low-flow oxygen


MEDICINE & PHARMACOLOGY, Pathology & Pathobiology

Comments (1)

Comment 1
Received: 20 April 2020
The commenter has declared there is no conflict of interests.
Comment: This article has not been formally published in an international journal. We hope that some clinicians are willing to testify our hypothesis. If clinical practices proved the feasibility of the therapeutic regimen, we hope that you could recommend this hypothesis to the journal when you submit your relevant research paper. Thank you in advance.
Sincerely from the authors.
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