Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

An Oral Live Attenuated Vaccine Strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (2019-nCoV)

Version 1 : Received: 6 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (13:10:50 CEST)

How to cite: Sanal, M.G.; Dubey, R.C. An Oral Live Attenuated Vaccine Strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (2019-nCoV). Preprints 2020, 2020040153 (doi: 10.20944/preprints202004.0153.v1). Sanal, M.G.; Dubey, R.C. An Oral Live Attenuated Vaccine Strategy against Severe Acute Respiratory Syndrome Coronavirus 2 (2019-nCoV). Preprints 2020, 2020040153 (doi: 10.20944/preprints202004.0153.v1).

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2/2019-nCoV) infection is an emerging pandemic. The virus binds to angiotensin converting enzyme 2 (ACE2) and TMPRSS2 which are abundantly expressed on various human cells including lung epithelial cells and intestinal cells and the virus can infect these cells. Currently no specific treatments or vaccines are available for this disease. A per oral live attenuated vaccine can be beneficial in SARS-Cov-2 infection because the attenuated virus initially infects the gut, stimulates the mucosa associated immune system sparing the respiratory system during the initial immune response. The live virus can also spread in the community boosting herd immunity.

Subject Areas

Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; COVID-19; angiotensin converting enzyme 2; Receptor; Live Attenuated Oral Vaccine; Intestine; proximal and distal enterocytes; herd immunity

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