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Preprint
Hypothesis
ACE Inhibitors and AT1R Blockers for COVID-2019: Friends or Foes ?
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This version is not peer-reviewed
Preprints on COVID-19 and SARS-CoV-2
Abstract
Human respiratory beta coronavirus are emerging causes for Public Health Emergencies of International Concern (PHEIC). SARS-CoV2 is circulating worldwide since November 2019. We review here the cardiovascular morbidity and mortality in COVID-19, and data supporting the role for dysregulation of the RAS counterregulatory axis due to binding of SARS-CoV2 S protein to ACE2 receptor. Since this counterregulatory axis provides benefits not only on the cardiovascular front but also in acute lung injury, we speculate on potential use of ACE inhibitors and AT1R blockers in critically ill COVID-19 patients, and report current evidences.
Keywords:
Subject: Biology and Life Sciences - Virology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Submitted:
21 April 2020
Posted:
22 April 2020
You are already at the latest version
Alerts
This version is not peer-reviewed
Preprints on COVID-19 and SARS-CoV-2
Submitted:
21 April 2020
Posted:
22 April 2020
You are already at the latest version
Alerts
Abstract
Human respiratory beta coronavirus are emerging causes for Public Health Emergencies of International Concern (PHEIC). SARS-CoV2 is circulating worldwide since November 2019. We review here the cardiovascular morbidity and mortality in COVID-19, and data supporting the role for dysregulation of the RAS counterregulatory axis due to binding of SARS-CoV2 S protein to ACE2 receptor. Since this counterregulatory axis provides benefits not only on the cardiovascular front but also in acute lung injury, we speculate on potential use of ACE inhibitors and AT1R blockers in critically ill COVID-19 patients, and report current evidences.
Keywords:
Subject: Biology and Life Sciences - Virology
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
Blood ACE2 protein level correlates with COVID-19 severity
Oksana Shevchuk
et al.
,
2023
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