ACE Inhibitors and AT1R Blockers for COVID-2019: Friends or Foes ?

Daniele Focosi; Marco Tuccori; Fabrizio Maggi

doi:10.20944/preprints202004.0151.v2

Preprint Hypothesis Version 2 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 8 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (12:34:46 CEST)
Version 2 : Received: 21 April 2020 / Approved: 22 April 2020 / Online: 22 April 2020 (09:46:54 CEST)

Human respiratory beta coronavirus are emerging causes for Public Health Emergencies of International Concern (PHEIC). SARS-CoV2 is circulating worldwide since November 2019. We review here the cardiovascular morbidity and mortality in COVID-19, and data supporting the role for dysregulation of the RAS counterregulatory axis due to binding of SARS-CoV2 S protein to ACE2 receptor. Since this counterregulatory axis provides benefits not only on the cardiovascular front but also in acute lung injury, we speculate on potential use of ACE inhibitors and AT₁R blockers in critically ill COVID-19 patients, and report current evidences.

COVID-19; ACEI; ARB; SARS; ALI; ARDS

Comment 1

Received: 22 April 2020
Commenter: Daniele Focosi
Commenter's Conflict of Interests: Author

Comment: Added more references from published trials.

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ACE Inhibitors and AT1R Blockers for COVID-2019: Friends or Foes ?

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