Working Paper Article Version 2 This version is not peer-reviewed

Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

Version 1 : Received: 5 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (11:09:23 CEST)
Version 2 : Received: 8 May 2020 / Approved: 9 May 2020 / Online: 9 May 2020 (08:43:08 CEST)

A peer-reviewed article of this Preprint also exists.


The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.


Sars-CoV-2; homology modelling; envelope membrane glycoprotein; Bat; Pangolin; Sars-CoV


Biology and Life Sciences, Virology

Comments (1)

Comment 1
Received: 9 May 2020
Commenter: Stefano Pascarella
Commenter's Conflict of Interests: Author
Comment: This is the final version of the manuscript accepted for publication by BioMed Research International. The title has been slightly changed. Abstract has been shortened. More variants of the SarS-CoV-2 Envelope and Membrane proteins have been compare to the Bat and Pangolin counterparts. Figures are more complete and accurate. Supplementary data are also provided.
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