Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

Martina Bianchi; Domenico Benvenuto; Marta Giovanetti; Silvia Angeletti; Massimo Ciccozzi; Stefano Pascarella

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preprints.org > biology and life sciences > virology > 202004.0089.v2

Working Paper Article Version 2 This version is not peer-reviewed

Sars-CoV-2 Envelope and Membrane Proteins: Structural Differences Linked to Virus Characteristics?

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Version 1 : Received: 5 April 2020 / Approved: 7 April 2020 / Online: 7 April 2020 (11:09:23 CEST)
Version 2 : Received: 8 May 2020 / Approved: 9 May 2020 / Online: 9 May 2020 (08:43:08 CEST)

A peer-reviewed article of this Preprint also exists.

Abstract

The Coronavirus Disease 2019 (COVID-19) is a new viral infection caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2). Genomic analyses have revealed that SARS-CoV-2 is related to Pangolin and Bat coronaviruses. In this report, a structural comparison between the Sars-CoV-2 Envelope and Membrane proteins from different human isolates with homologous proteins from closely related viruses is described. The analyses here reported show the high structural similarity of Envelope and Membrane proteins to the counterparts from Pangolin and Bat coronavirus isolates. However, the comparisons have also highlighted structural differences specific of Sars-CoV-2 proteins which may be correlated to the cross-species transmission and/or to the properties of the virus. Structural modelling has been applied to map the variant sites onto the predicted three-dimensional structure of the Envelope and Membrane proteins.

Keywords

Sars-CoV-2; homology modelling; envelope membrane glycoprotein; Bat; Pangolin; Sars-CoV

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comments (1)

Comment 1

Received: 9 May 2020
Commenter: Stefano Pascarella
Commenter's Conflict of Interests: Author

Comment: This is the final version of the manuscript accepted for publication by BioMed Research International. The title has been slightly changed. Abstract has been shortened. More variants of the SarS-CoV-2 Envelope and Membrane proteins have been compare to the Bat and Pangolin counterparts. Figures are more complete and accurate. Supplementary data are also provided.

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