COVID-19 Virus Infection and Transmission are Observably Less in Highly Dengue-endemic Countries: Can Dengue Vaccines be “Repurposed” to Prevent COVID-19?

Subhajit Biswas; Soumi Sukla

doi:10.20944/preprints202004.0040.v3

Comment 1

Received: 5 May 2020
Commenter: Subhajit Biswas
Commenter's Conflict of Interests: Author

Comment: We have elaborated on the abstract part and made some editings in the main text to enhance clarity.

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Comment 2

Received: 20 June 2020
Commenter:

Subhajit Biswas

The commenter has declared there is no conflict of interests.

Comment: In connection to this research, we have done computational analysis on possibilities of interaction between Dengue virus antibodies and SARS-CoV-2 virus and came up with results that further support our hypothesis.

You can read our analysis online, and let us know your comments.

Title of publication: Computational modelling predicts that Dengue virus antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity?

(Link: https://osf.io/dutx4)

On the basis of our observations that COVID-19 and Dengue severity maps do not tend to overlap and the fact that serological cross-reactivity has been reported for COVID-19 antibodies with Dengue antigen (s), together with results from our computational studies, we are of opinion that serology-based diagnosis needs to be complemented with NAT/virus antigen detection-based tests for definitive diagnosis/sero-surveillance of either disease in regions where both of these viruses are now co-existent.

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Comment 3

Received: 14 July 2020
The commenter has declared there is no conflict of interests.

Comment: Our pilot level results emphasize the importance of NAT and/or virus antigen tests to complement sero-surveillance for definitive diagnosis of COVID-19/Dengue in regions where both viruses are co-endemic.

Please read our latest findings:

Dengue antibodies can cross-react with SARS-CoV-2 and vice versa-Antibody detection kits can give false-positive results for both viruses in regions where both COVID-19 and Dengue co-exist.

https://www.medrxiv.org/content/10.1101/2020.07.03.20145797v1.article-metrics
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COVID-19 Virus Infection and Transmission are Observably Less in Highly Dengue-endemic Countries: Can Dengue Vaccines be “Repurposed” to Prevent COVID-19?

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