Working Paper Review Version 2 This version is not peer-reviewed

COVID-19 Virus Infection and Transmission are Observably Less in Highly Dengue-endemic Countries: Can Dengue Vaccines be “Repurposed” to Prevent COVID-19?

Version 1 : Received: 2 April 2020 / Approved: 3 April 2020 / Online: 3 April 2020 (15:48:36 CEST)
Version 2 : Received: 13 April 2020 / Approved: 14 April 2020 / Online: 14 April 2020 (08:49:03 CEST)
Version 3 : Received: 2 May 2020 / Approved: 5 May 2020 / Online: 5 May 2020 (03:00:34 CEST)

A peer-reviewed article of this Preprint also exists.


We observed that global severity maps of ongoing dengue epidemic and COVID-19 pandemic do not overlap. Countries where dengue is highly endemic (>1.5 million cases/year) appear to be less hit by COVID-19 pandemic in terms of infection and transmission. Other evidences also support our proposition that pre-exposure to other wide-spread viral infections like dengue may thwart the spread of the COVID-19 pandemic.


Dengue; COVID-19; SARS-CoV-2; epidemiology; infection; mortality; cross-protection; Dengue vaccine; ELISA; Dengvaxia


Biology and Life Sciences, Virology

Comments (1)

Comment 1
Received: 14 April 2020
Commenter: Subhajit Biswas
Commenter's Conflict of Interests: Author
Comment: Dear Editor,

We have changed the title and included more data and a Table in this version (v2).

Best regards.
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