Preserved in Portico This version is not peer-reviewed
A Flexible Genome-Scale SARS-CoV-2 Clone Resource
: Received: 31 March 2020 / Approved: 2 April 2020 / Online: 2 April 2020 (04:15:54 CEST)
: Received: 3 May 2020 / Approved: 4 May 2020 / Online: 4 May 2020 (18:28:01 CEST)
: Received: 16 June 2020 / Approved: 16 June 2020 / Online: 16 June 2020 (09:37:50 CEST)
: Received: 19 June 2020 / Approved: 21 June 2020 / Online: 21 June 2020 (15:38:18 CEST)
: Received: 7 July 2020 / Approved: 7 July 2020 / Online: 7 July 2020 (18:09:21 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: G3 2020, 10
The world is facing a major health crisis, the global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus, for which no approved antiviral agents or vaccines are currently available. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer into a variety of expression and tagging vectors. The collection is freely available via Addgene. We hope that widespread availability of this SARS-CoV-2 resource will enable many subsequent molecular studies to better understand the viral life cycle and how to block it.
SARS-CoV-2; coding sequence collection; gateway-compatible
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.