Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Accelerated Production of Hesperidin-rich Citrus Pectin from Waste Citrus Peel for Prevention and Therapy of COVID-19

Version 1 : Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (13:59:28 CET)

A peer-reviewed article of this Preprint also exists.

Journal reference: Processes 2020
DOI: 10.3390/pr8050549


Computational studies suggest that hesperidin, a flavonoid abundant in citrus peel, binding the three main cellular receptors of SARS-CoV-2 virus can act in the prophylaxis and treatment of COVID-19. Herein we urge the uptake of hydrodynamic cavitation industrial-scale reactors based on the low cost, reliable Venturi tube for the extraction of citrus pectin rich in hesperidin (and in other bioflavonoids including naringing) by very fast processing of waste orange peel or waste lemon peel in water only. A device able to process up to 500 kg of waste peels per session, similar to the one lately deployed in Italy for hydrodynamic cavitation-assisted brewing, is capable to provide 36,000 doses of 1000 mg hesperidin per day.


hesperidin; COVID-19; pectin; flavonoids; hydrodynamic cavitation; IntegroPectin



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