Preprint Review Version 1 This version is not peer-reviewed

In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019

Version 1 : Received: 20 March 2020 / Approved: 24 March 2020 / Online: 24 March 2020 (03:16:22 CET)

How to cite: Verma, S.K. In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019 . Preprints 2020, 2020030353 (doi: 10.20944/preprints202003.0353.v1). Verma, S.K. In Search of Feasible Interventions for the Prevention and Cure of Novel Coronavirus Disease 2019 . Preprints 2020, 2020030353 (doi: 10.20944/preprints202003.0353.v1).

Abstract

COVID-19 (coronavirus disease 2019) is a public health emergency of international concern caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As of this time, there is no known effective pharmaceutical, phytopharmaceutical or traditional medicine for cure or prevention of COVID-19, although it is urgently needed. In this review, based on the current understanding of the disease molecular mechanisms of novel Coronavirus SARS-CoV-2 and its closest relative SARS-CoV and other human Coronaviruses, I have identified some naturally occurring plant based substances and Ayurvedic medicinal herbs that could feasibly be tested as a matter of urgency for prevention as well as therapeutic option for COVID-19 in India and other parts of the world. I conclude that dried rhizome of Curcuma longa L. i.e. turmeric, and its active ingredient curcumin may be effective in preventing as well as cure the COVID-19 pandemic due to its proven antiviral activities, this however need to be tested by appropriate clinical trials as research priority.

Subject Areas

COVID-19; SARS-CoV-2; Severe Acute Respiratory Syndrome Coronavirus-2; Curcumin

Comments (6)

Comment 1
Received: 24 March 2020
Commenter: Nisarg Joshi
The commenter has declared there is no conflict of interests.
Comment: Thank you Dr Sunil Verma for this important contribution!
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Response 1 to Comment 1
Received: 26 March 2020
Commenter: Ajay Kumar Yadav
The commenter has declared there is no conflict of interests.
Comment: COVID 19: Nice comprehensive approach, actually need proper research based complete analysis before treating. Mentioned plant extracts shows CD13 inhibition, moreover before taking in regime we need to be sure that ACE2, not to be compromised or getting stable related with diabetis or coronary heart patient. Best example about Ibuprofen use taken carefully (reversal detrimental effect) while discussing at the same time about plant extracts.

Due to this lacking any treatment at this moment, home isolation, social distancing is only the option along with proper hygiene and immune boosters.
Comment 2
Received: 25 March 2020
Commenter: Dr. Shreyas Goswami
The commenter has declared there is no conflict of interests.
Comment: A very extensive and well researched review piece. Thanks to Dr. Sunil Kumar Verma for this detailed review.
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Comment 3
Received: 26 March 2020
Commenter: dileep shukla
The commenter has declared there is no conflict of interests.
Comment: Thank you Dr. sunil Kumar verma sir for your contribution to country at this time.
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Comment 4
Received: 26 March 2020
Commenter: Mahendra K. Singh, Ph.D.
The commenter has declared there is no conflict of interests.
Comment: It is a wonderfully written article providing deep insight into mechanism of action for COVID19 infection and possible remedies using plant based therapeutics. I agree with author's suggestion of exploring prophylactic role of turmeric in countries like India where it is difficult to provide modern medical facilities to everyone due to its significant large population. It is important that regulatory authorities those conduct clinical trials take cognizance of this article and start appropriate clinical trials in their populations at risk as soon as possible to prevent this pandemic.
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Response 1 to Comment 4
Received: 31 March 2020
Commenter: Sunil Verma
The commenter has declared there is no conflict of interests.
Comment: Thanks Dr Mahendra!

Today Government of India through its Press Information Bureau has released a press note and recommended Golden Milk i.e. Haldi Milk to fight against Chinese CORONA Virus.

Here is the link

https://pib.gov.in/PressReleseDetailm.aspx?PRID=1609524
Dr SK Verma

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