Working Paper Review Version 1 This version is not peer-reviewed

Report of a ‘Consensus’ on the Lines of Treatment for Primary Immune Thrombocytopenia in Adults, Promoted by the Italian Gruppo di Studio delle Piastrine

Version 1 : Received: 27 February 2020 / Approved: 28 February 2020 / Online: 28 February 2020 (16:18:38 CET)

How to cite: Cirasino, L.; Robino, A.M.; Podda, G.; Andrès, E.; Despotovic, J.M.; Elalfy, M.; Holbro, A.; Kondo, T.; Lambert, M.P.; Loggetto, S.R.; McCrae, K.R.; Wook Lee, J.; Cattaneo, M. Report of a ‘Consensus’ on the Lines of Treatment for Primary Immune Thrombocytopenia in Adults, Promoted by the Italian Gruppo di Studio delle Piastrine. Preprints 2020, 2020020445 Cirasino, L.; Robino, A.M.; Podda, G.; Andrès, E.; Despotovic, J.M.; Elalfy, M.; Holbro, A.; Kondo, T.; Lambert, M.P.; Loggetto, S.R.; McCrae, K.R.; Wook Lee, J.; Cattaneo, M. Report of a ‘Consensus’ on the Lines of Treatment for Primary Immune Thrombocytopenia in Adults, Promoted by the Italian Gruppo di Studio delle Piastrine. Preprints 2020, 2020020445

Abstract

Despite the publication in 2009 of a paper on ‘terms and definitions of immune thrombocytopenia’, (ITP) some unresolved issues remain and are reflected by the disagreement in the treatment suggested for primary ITP in adults. Considering that these disagreements could be ascribed to non-shared goals, a ‘consensus’ to classify the different lines of treatment for primary ITP in adults according to their indications and goals was proposed in October 2018 to the XIX annual meeting of the Italian Gruppo di Studio delle Piastrine (GSP), a non-profit platelet study group of scientists and physicians. Having approved the project, 60 potential co-authors and experts in the world were invited to take part to a consensus through e-Delphy method and nine of the 12 who initially accepted the invitation completed the work. Agreement was reached on a classification of four lines of treatment for primary ITP in adults based on their indications and goals. The consensus obtained regarded also the criteria, ‘timing’ included, to consider practicable elective splenectomy in these patients. In our opinion, the classification of the lines of treatment for primary ITP in adults here proposed could facilitate the realization of better shared evidence-based guidelines for the treatment of the disease.

Subject Areas

adult 1; classification 2; consensus 3; goal 4; guideline 5; immune thrombocytopenia 6; indication 7; ITP 8; therapy 9

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