Working PaperBrief ReportVersion 1This version is not peer-reviewed
Single-Cell RNA Expression Profiling Shows that ACE2, the Putative Receptor of Wuhan 2019-nCoV, Has Significant Expression in the Nasal, Mouth, Lung and Colon Tissues, and Tends to be Co-Expressed with HLA-DRB1 in the Four Tissues
Version 1
: Received: 16 February 2020 / Approved: 17 February 2020 / Online: 17 February 2020 (15:25:43 CET)
How to cite:
Wu, C.; Zheng, M. Single-Cell RNA Expression Profiling Shows that ACE2, the Putative Receptor of Wuhan 2019-nCoV, Has Significant Expression in the Nasal, Mouth, Lung and Colon Tissues, and Tends to be Co-Expressed with HLA-DRB1 in the Four Tissues. Preprints2020, 2020020247
Wu, C.; Zheng, M. Single-Cell RNA Expression Profiling Shows that ACE2, the Putative Receptor of Wuhan 2019-nCoV, Has Significant Expression in the Nasal, Mouth, Lung and Colon Tissues, and Tends to be Co-Expressed with HLA-DRB1 in the Four Tissues. Preprints 2020, 2020020247
Cite as:
Wu, C.; Zheng, M. Single-Cell RNA Expression Profiling Shows that ACE2, the Putative Receptor of Wuhan 2019-nCoV, Has Significant Expression in the Nasal, Mouth, Lung and Colon Tissues, and Tends to be Co-Expressed with HLA-DRB1 in the Four Tissues. Preprints2020, 2020020247
Wu, C.; Zheng, M. Single-Cell RNA Expression Profiling Shows that ACE2, the Putative Receptor of Wuhan 2019-nCoV, Has Significant Expression in the Nasal, Mouth, Lung and Colon Tissues, and Tends to be Co-Expressed with HLA-DRB1 in the Four Tissues. Preprints 2020, 2020020247
Abstract
A novel coronavirus (2019-nCoV) was first identified in Wuhan, Hubei Province, and then spreads to the other Provinces of China. 2019-nCoV was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-CoV. Previous studies have found ACE2 is abundantly present in humans in the epithelia of the lung and small intestines, and they found ACE2 expression in the basal layer of the non-keratinizing squamous epithelium in nasal and oral mucosa and the nasopharynx. Here based on the public single-cell RNA-Seq datasets, we analyzed the ACE2 expression in the nasal, mouth, lung, and colon tissues. We find that the number of ACE2-expressing cells in the nasal tissue and mouth is comparable to the number of ACE2-expressing cells in the lung tissue and colon. We also find that ACE2 tends to be co-expressed with HLA-DRB1, which plays a central role in the immune system by presenting peptides derived from extracellular proteins, in the nasal, mouth, lung, and colon tissues at single-cell resolution. We hope this provides valuable information for virus-prevention strategy and therapeutic strategy development.
Keywords
2019-nCoV; ACE2; HLA-DRB1
Subject
LIFE SCIENCES, Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
