Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Pulmonary Pathology of Early Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients with Lung Cancer

Version 1 : Received: 15 February 2020 / Approved: 16 February 2020 / Online: 16 February 2020 (14:41:28 CET)
Version 2 : Received: 27 February 2020 / Approved: 2 March 2020 / Online: 2 March 2020 (01:34:58 CET)

A peer-reviewed article of this Preprint also exists.

Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer, Journal of Thoracic Oncology (2020), doi: https://doi.org/10.1016/j.jtho.2020.02.010. Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer, Journal of Thoracic Oncology (2020), doi: https://doi.org/10.1016/j.jtho.2020.02.010.

Journal reference: Journal of Thoracic Oncology 2020
DOI: 10.1016/j.jtho.2020.02.010

Abstract

There is currently a lack of pathologic data on the novel coronavirus (SARS-CoV-2) pneumonia, or COVID-19, from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of surgery. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that, apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Since both patients did not exhibit symptoms of pneumonia at the time of surgery, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.

Subject Areas

coronavirus; COVID-19 pneumonia; pathology; SARS-CoV-2

Comments (1)

Comment 1
Received: 2 March 2020
Commenter: Shu-Yuan Xiao
Commenter's Conflict of Interests: Author
Comment: Title changed from "Pulmonary Pathology of Early Phase SARS-COV-2 Pneumonia" to "Pulmonary Pathology of Early Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients with Lung Cancer"; Typos corrected; Discussion section has been revised.
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