Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Insulin Resistance in Diabetes: The Promise of Using Induced Pluripotent Stem Cell Technology

Version 1 : Received: 6 February 2020 / Approved: 7 February 2020 / Online: 7 February 2020 (11:45:04 CET)

How to cite: Elsayed, A.; Vimalraj, S.; Nandakumar, M.; Abdelalim, E. Insulin Resistance in Diabetes: The Promise of Using Induced Pluripotent Stem Cell Technology. Preprints 2020, 2020020098 (doi: 10.20944/preprints202002.0098.v1). Elsayed, A.; Vimalraj, S.; Nandakumar, M.; Abdelalim, E. Insulin Resistance in Diabetes: The Promise of Using Induced Pluripotent Stem Cell Technology. Preprints 2020, 2020020098 (doi: 10.20944/preprints202002.0098.v1).

Abstract

In this review, we discuss the insulin resistance (IR) and its development in the insulin target tissues that leads to diabetes. Also, we highlight the use of induced pluripotent stem cells (iPSCs) to understand the mechanisms underlying the development of IR. IR is associated with several metabolic disorders, including type 2 diabetes (T2D). The development of IR in insulin target tissues involves genetic and acquired factors. Persons at genetic risk for T2D tend to develop IR several years before glucose intolerance. Although there are currently several mouse models for both IR and T2D that had provided a lot of information about the disease, these models cannot recapitulate all the aspects of this complex disease as seen in each individual. Patient-specific iPSCs can overcome the hurdles faced with the classical mouse models for studying IR. iPSC technology can generate cells genetically identical to IR individuals, which can help in distinguishing between genetic and acquired defects in insulin sensitivity. Combining the technologies of the genome editing and iPSCs may provide important information about the inherited factors underlying the development of different forms of IR. Further studies are required to fill the gaps in understanding the pathogenesis of IR and diabetes.

Subject Areas

Type 2 diabetes; insulin target tissues; iPSCs; genetic factors; disease modeling

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.