Preprint Review Version 1 This version is not peer-reviewed

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Version 1 : Received: 20 January 2020 / Approved: 21 January 2020 / Online: 21 January 2020 (03:15:50 CET)

How to cite: Kaur, R.; Sharma, P.; Gupta, G.K.; Ntie-Kang, F.; Kumar, D. Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products. Preprints 2020, 2020010230 (doi: 10.20944/preprints202001.0230.v1). Kaur, R.; Sharma, P.; Gupta, G.K.; Ntie-Kang, F.; Kumar, D. Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products. Preprints 2020, 2020010230 (doi: 10.20944/preprints202001.0230.v1).

Abstract

Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.

Subject Areas

AIDS; anti-HIV; natural products; SARs

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