Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Exceptional Antioxidant, Non-Cytotoxic Activity of Integral Lemon Pectin from Hydrodynamic Cavitation

Version 1 : Received: 15 January 2020 / Approved: 16 January 2020 / Online: 16 January 2020 (03:14:23 CET)
Version 2 : Received: 17 March 2020 / Approved: 18 March 2020 / Online: 18 March 2020 (02:37:32 CET)
Version 3 : Received: 30 March 2020 / Approved: 31 March 2020 / Online: 31 March 2020 (05:00:13 CEST)

A peer-reviewed article of this Preprint also exists.

Journal reference: ChemistrySelect 2020
DOI: 10.1002/slct.202000375


Lemon pectin extracted along with water-soluble flavonoids and other phytochemicals from citrus industry’s waste lemon peel via hydrodynamic cavitation in water, directly at pre-industrial scale and further isolated via freeze drying, shows exceptionally high antioxidant and non-cytotoxic activity. Preliminary investigation indicates also significant antimicrobial activity. These findings open the route to the development of new nutraceutical and healthcare application of a versatile biopolymer endowed with new functionality, rapidly and conveniently obtained from an abundant by-product of the agrofood industry.


pectin; antioxidant; lemon; flavonoids; hydrodynamic cavitation; IntegroPectin


LIFE SCIENCES, Biochemistry

Comments (1)

Comment 1
Received: 18 March 2020
Commenter: Mario Pagliaro
Commenter's Conflict of Interests: Author
Comment: Manuscript revised upon peer review at a major general chemistry journal published in Europe. The new manuscript is organized in sections and includes relevant new discussion on the antioxidant activity of IntegroPectin as well as comparison between hydrodynamic cavitation and microwave hydrodistillation, hydrodiffusion and gravity extraction methods applied to waste citrus peel.
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