Version 1
: Received: 27 November 2019 / Approved: 29 November 2019 / Online: 29 November 2019 (02:26:36 CET)
How to cite:
El Azab, I.H.; Elkanzi, N.A. Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents. Preprints2019, 2019110364. https://doi.org/10.20944/preprints201911.0364.v1
El Azab, I.H.; Elkanzi, N.A. Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents. Preprints 2019, 2019110364. https://doi.org/10.20944/preprints201911.0364.v1
El Azab, I.H.; Elkanzi, N.A. Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents. Preprints2019, 2019110364. https://doi.org/10.20944/preprints201911.0364.v1
APA Style
El Azab, I.H., & Elkanzi, N.A. (2019). Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-<em>c</em>][1,2,4]Triazolo[3,4-<em>f</em>][1,2,4]Triazines as Antimicrobial Agents. Preprints. https://doi.org/10.20944/preprints201911.0364.v1
Chicago/Turabian Style
El Azab, I.H. and Nadia A.A. Elkanzi. 2019 "Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-<em>c</em>][1,2,4]Triazolo[3,4-<em>f</em>][1,2,4]Triazines as Antimicrobial Agents" Preprints. https://doi.org/10.20944/preprints201911.0364.v1
Abstract
In our tactic to construct bio-active molecules, a series of novel pyrimido[2,1-c][1,2,4]triazine-3,4-diones based heterocycles, were synthesized and evaluated for their in vitro antimicrobial impacts. The exploratory bioassay results declared that, the majority of the evaluated compounds exhibited considerable anti-microbial activity comparable to the reference drugs. Conjugates 15j, 15f, 15i, 15h, 15g and 15a were found to be the most potent antibacterial, indicating that conjugates bearing electron-attracting substituents exhibited higher potency than these with electron-releasing substituents.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
