Preprint Article Version 1 This version is not peer-reviewed

Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents

Version 1 : Received: 27 November 2019 / Approved: 29 November 2019 / Online: 29 November 2019 (02:26:36 CET)

How to cite: El Azab, I.H.; Elkanzi, N.A. Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents. Preprints 2019, 2019110364 (doi: 10.20944/preprints201911.0364.v1). El Azab, I.H.; Elkanzi, N.A. Design, Synthesis and Pharmacological Evaluation of Novel Annelated Pyrimido[2,1-c][1,2,4]Triazolo[3,4-f][1,2,4]Triazines as Antimicrobial Agents. Preprints 2019, 2019110364 (doi: 10.20944/preprints201911.0364.v1).

Abstract

In our tactic to construct bio-active molecules, a series of novel pyrimido[2,1-c][1,2,4]triazine-3,4-diones based heterocycles, were synthesized and evaluated for their in vitro antimicrobial impacts. The exploratory bioassay results declared that, the majority of the evaluated compounds exhibited considerable anti-microbial activity comparable to the reference drugs. Conjugates 15j, 15f, 15i, 15h, 15g and 15a were found to be the most potent antibacterial, indicating that conjugates bearing electron-attracting substituents exhibited higher potency than these with electron-releasing substituents.

Subject Areas

mannich reaction; 1,2,4-triazine; pyrimidine; 1,2,4-triazole; n-heterocycles; anti-microbial activity

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