Preprint Review Version 1 This version is not peer-reviewed

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

Version 1 : Received: 25 November 2019 / Approved: 27 November 2019 / Online: 27 November 2019 (03:57:04 CET)

How to cite: Ancuceanu, R.; Anghel, A.I.; Ionescu, C.; Hovaneț, M.V.; Cojocaru-Toma, M.; Dinu, M. Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study. Preprints 2019, 2019110325 (doi: 10.20944/preprints201911.0325.v1). Ancuceanu, R.; Anghel, A.I.; Ionescu, C.; Hovaneț, M.V.; Cojocaru-Toma, M.; Dinu, M. Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study. Preprints 2019, 2019110325 (doi: 10.20944/preprints201911.0325.v1).

Abstract

It is currently recognized that an injudicious strategy in the last decades has been not only focusing of research typically on caries in children, but also the narrow focusing on fluoride, because despite sufficient availability of fluoride in water and oral healthcare products, caries levels escalate steadily as people get older and caries remain a main public health issue to be settled. In the last two decades the scientific community intensified efforts of exploring other products for caries prevention, herbal products being one of these approaches. Because preliminary evidence indicated that clinical trials for caries prevention with herbal products are heterogeneous in design, quality and products evaluated, we performed a scoping review intended to explore the main characteristics of such clinical trials. From an initial collection of 1986 unique papers from different literature databases, 56 articles satisfied the inclusion and exclusion criteria. The species investigated, dosage forms, study designs, duration of intervention, controls, endpoints, quality of reporting and risk of bias are discussed. 85.71% of the trials reviewed here reported positive results but given the methodological flaws and biases affecting them, it is difficult to conclude on the efficacy of those products based on the studies published thus far.

Subject Areas

dental caries; prevention; clinical trials; herbal; scoping review

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